Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study
SM and MAH are funded by a Medical Research Council Experimental Medicine Challenge Grant (MR/N026969/1). SM, MAH, and OGOD are also supported by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Trust. This study has been funded by the Institute of Health Ca...
| Authors: | ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2025 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12328/4837 |
| Online Access: | http://hdl.handle.net/20.500.12328/4837 https://dx.doi.org/10.1002/brb3.70380 |
| Access Level: | Open access |
| Keyword: | ACT BATD Chronic pain Depression fMRI Dolor crònic Depressió Dolor crónico Depresión 61 |
| _version_ | 1878729550890795008 |
|---|---|
| author | Medina, Sonia |
| author2 | García Forero, Carlos Sanabria-Mazo, Juan P. Rodríguez Freire, Carla Navarrete, Jaime O'Daly, Owen G. Howard, Matthew A. Luciano, Juan V. |
| author2_role | author author author author author author author |
| author_browse | García Forero, Carlos Howard, Matthew A. Luciano, Juan V. Medina, Sonia Navarrete, Jaime O'Daly, Owen G. Rodríguez Freire, Carla Sanabria-Mazo, Juan P. |
| author_facet | Medina, Sonia García Forero, Carlos Sanabria-Mazo, Juan P. Rodríguez Freire, Carla Navarrete, Jaime O'Daly, Owen G. Howard, Matthew A. Luciano, Juan V. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | SM and MAH are funded by a Medical Research Council Experimental Medicine Challenge Grant (MR/N026969/1). SM, MAH, and OGOD are also supported by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Trust. This study has been funded by the Institute of Health Carlos III (ISCIII; PI19/00112 & PI16/00165, both cofinanced with European Union ERDF funds). JPS-M has a PFIS contract from the ISCIII (FI20/00034). CR has a research contract from the ISCIII (ICI20/00080). We thank the CIBER of Epidemiology and Public Health (CIBERESP CB22/02/00052; ISCIII) for its support. The ISCIII and CIBER did not play any role in the analysis and interpretation of data, in the writing of the manuscript, or in the decision to submit the paper for publication. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_0a2f261aafbb028fbb37d982f8d667cc |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:20.500.12328/4837 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study Medina, Sonia García Forero, Carlos Sanabria-Mazo, Juan P. Rodríguez Freire, Carla Navarrete, Jaime O'Daly, Owen G. Howard, Matthew A. Luciano, Juan V. ACT BATD Chronic pain Depression fMRI Dolor crònic Depressió Dolor crónico Depresión 61 SM and MAH are funded by a Medical Research Council Experimental Medicine Challenge Grant (MR/N026969/1). SM, MAH, and OGOD are also supported by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Trust. This study has been funded by the Institute of Health Carlos III (ISCIII; PI19/00112 & PI16/00165, both cofinanced with European Union ERDF funds). JPS-M has a PFIS contract from the ISCIII (FI20/00034). CR has a research contract from the ISCIII (ICI20/00080). We thank the CIBER of Epidemiology and Public Health (CIBERESP CB22/02/00052; ISCIII) for its support. The ISCIII and CIBER did not play any role in the analysis and interpretation of data, in the writing of the manuscript, or in the decision to submit the paper for publication. Introduction: Chronic low back pain (CLBP) is a prevalent and debilitating condition. Cognitive behavioral therapy (CBT) can improve coping mechanisms for CLBP and pain-related outcomes. However, the mechanisms by which they do so remain undetermined. We explored the neural correlates of CLBP symptoms and CBT action using functional magnetic resonance imaging (fMRI) in women with CLBP and comorbid depression. Methods: Forty individuals underwent fMRI followed by 8 weeks of either treatment as usual (TAU) or one of two CBT in addition to TAU: acceptance and commitment therapy (ACT) or behavioral activation treatment for depression (BATD). Pain intensity, depression, psychological inflexibility, and pain catastrophizing scores were obtained at baseline and follow-up. Functional connectivity (FC) patterns of the salience network (SN), sensorimotor network (SMN), and the mesolimbic pathway (MLP), derived from resting-state fMRI examination were correlated with both baseline and delta (baseline—follow-up) pain-related psychological measures. Results: Individuals receiving ACT and BATD showed reduced depression, psychological inflexibility, and pain catastrophizing. Strong baseline connectivity of the SN and SMN corresponded with higher pain intensity, but strong connectivity of the MLP and precuneus corresponded with lower pain intensity. Pain intensity changes correlated with mesolimbic-salience connectivity following ACT, and with sensorimotor connectivity following BATD. Specifically, stronger baseline FC between the MLP and posterior insula predicted greater pain intensity reduction with ACT, while stronger FC between the SMN and secondary somatosensory cortex predicted greater pain intensity reduction with BATD. FC of the SN correlated with changes in psychological inflexibility across both therapies. Conclusions: We illustrate the potential of FC as a biomarker of CLBP plus depression and the response to CBT. Our data suggest ACT and BATD have differing underlying brain mechanisms. These findings indicate that FC biomarkers could guide personalized treatment, improving individual outcomes. info:eu-repo/semantics/publishedVersion Wiley http://hdl.handle.net/20.500.12328/4837 https://dx.doi.org/10.1002/brb3.70380 |
| spellingShingle | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study Medina, Sonia ACT BATD Chronic pain Depression fMRI Dolor crònic Depressió Dolor crónico Depresión 61 |
| title | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| title_full | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| title_fullStr | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| title_full_unstemmed | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| title_short | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| title_sort | Baseline functional connectivity of the mesolimbic, salience, and sensorimotor systems predicts responses to psychological therapies for chronic low back pain with comorbid depression: a functional MRI study |
| topic | ACT BATD Chronic pain Depression fMRI Dolor crònic Depressió Dolor crónico Depresión 61 |
| topic_facet | ACT BATD Chronic pain Depression fMRI Dolor crònic Depressió Dolor crónico Depresión 61 |
| url | http://hdl.handle.net/20.500.12328/4837 https://dx.doi.org/10.1002/brb3.70380 |