Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents
The use of Type III Deep Eutectic Solvents (DESs) as both solvents and cocatalysts enable the one-pot synthesis of several β-ketosulfides, structural motifs commonly found in biologically active compounds, via a multicomponent reaction (MCR) involving 2-bromoketones, alkyl or benzyl halides, and pot...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2026 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:dnet:idus________::8e86da0fb14190e99ba093f27ae7f92e |
| Online Access: | https://hdl.handle.net/11441/184433 https://doi.org/10.3390/molecules31040745 |
| Access Level: | Open access |
| Keyword: | Deep eutectic solvents E-factor Global warming potential Green chemistry Multicomponent reactions β-ketosulfides |
| _version_ | 1878729525222703104 |
|---|---|
| author | Falcini, Chiara |
| author2 | Jaén-Herrera, David Fernández Fernández, Rosario Fátima Alcántara, Andrés R. Gonzalo Calvo, Gonzalo de |
| author2_role | author author author author |
| author_browse | Alcántara, Andrés R. Falcini, Chiara Fernández Fernández, Rosario Fátima Gonzalo Calvo, Gonzalo de Jaén-Herrera, David |
| author_facet | Falcini, Chiara Jaén-Herrera, David Fernández Fernández, Rosario Fátima Alcántara, Andrés R. Gonzalo Calvo, Gonzalo de |
| author_role | author |
| collection | idUS. Depósito de Investigación de la Universidad de Sevilla |
| description | The use of Type III Deep Eutectic Solvents (DESs) as both solvents and cocatalysts enable the one-pot synthesis of several β-ketosulfides, structural motifs commonly found in biologically active compounds, via a multicomponent reaction (MCR) involving 2-bromoketones, alkyl or benzyl halides, and potassium thioacetate in basic medium. Under these conditions, it was possible to avoid not only the use of the non-eco-friendly solvent dimethylformamide (DMF), but also an additional hydrolytic step previously reported for the preparation of these molecules. The MCR conducted in the presence of the DES ChCl:Gly (1:2) was optimized through the evaluation of different reaction parameters. Notably, the non-conventional medium could be recycled up to four times without any appreciable loss of catalytic activity. Environmental metrics, including the E factor, E+ factor, and Global Warming Potential (GWP), were calculated for the process both in the presence and absence of the DES, demonstrating improved environmental performance when the DES was employed. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_09a68bfa25d8800a7d64f85da952b23f |
| institution | Universidad de Sevilla (US) |
| instname_str | Universidad de Sevilla (US) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dnet:idus________::8e86da0fb14190e99ba093f27ae7f92e |
| publishDate | 2026 |
| publishDateSort | 2026 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| publisherStr | Multidisciplinary Digital Publishing Institute (MDPI) |
| reponame_str | idUS. Depósito de Investigación de la Universidad de Sevilla |
| spelling | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents Falcini, Chiara Jaén-Herrera, David Fernández Fernández, Rosario Fátima Alcántara, Andrés R. Gonzalo Calvo, Gonzalo de Deep eutectic solvents E-factor Global warming potential Green chemistry Multicomponent reactions β-ketosulfides The use of Type III Deep Eutectic Solvents (DESs) as both solvents and cocatalysts enable the one-pot synthesis of several β-ketosulfides, structural motifs commonly found in biologically active compounds, via a multicomponent reaction (MCR) involving 2-bromoketones, alkyl or benzyl halides, and potassium thioacetate in basic medium. Under these conditions, it was possible to avoid not only the use of the non-eco-friendly solvent dimethylformamide (DMF), but also an additional hydrolytic step previously reported for the preparation of these molecules. The MCR conducted in the presence of the DES ChCl:Gly (1:2) was optimized through the evaluation of different reaction parameters. Notably, the non-conventional medium could be recycled up to four times without any appreciable loss of catalytic activity. Environmental metrics, including the E factor, E+ factor, and Global Warming Potential (GWP), were calculated for the process both in the presence and absence of the DES, demonstrating improved environmental performance when the DES was employed. Multidisciplinary Digital Publishing Institute (MDPI) https://hdl.handle.net/11441/184433 https://doi.org/10.3390/molecules31040745 |
| spellingShingle | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents Falcini, Chiara Deep eutectic solvents E-factor Global warming potential Green chemistry Multicomponent reactions β-ketosulfides |
| status_str | publishedVersion |
| title | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| title_full | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| title_fullStr | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| title_full_unstemmed | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| title_short | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| title_sort | Multicomponent Reaction for the Synthesis of β-Ketosulfides in Deep Eutectic Solvents |
| topic | Deep eutectic solvents E-factor Global warming potential Green chemistry Multicomponent reactions β-ketosulfides |
| topic_facet | Deep eutectic solvents E-factor Global warming potential Green chemistry Multicomponent reactions β-ketosulfides |
| url | https://hdl.handle.net/11441/184433 https://doi.org/10.3390/molecules31040745 |