LiverScreen project
The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:282714 |
| Online Access: | https://ddd.uab.cat/record/282714 https://dx.doi.org/urn:doi:10.1186/s12889-022-13724-6 |
| Access Level: | Open access |
| Keyword: | Cirrhosis Screening Liver fibrosis Chronic liver disease NAFLD NASH Vibration-controlled transient elastography |
| _version_ | 1878729515830607872 |
|---|---|
| author | Graupera, Isabel|||0000-0001-9170-9784 |
| author2 | Thiele, Maja Ma, Ann T.|||0000-0002-9059-111X Serra-Burriel, Miquel Pich, Judit Fabrellas, Núria|||0000-0001-6720-0291 Caballería, Llorenç|||0000-0002-7990-0719 de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M.|||0000-0002-3645-3293 Angeli, Paolo|||0000-0002-1913-0716 Tsochatzis, Emmanuel A. Guha, Indra Neil Garcia-Retortillo, M.|||0000-0001-6783-7604 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola, Adrià|||0000-0003-4832-5130 Soria, Anna|||0000-0001-5671-8343 Juan, Marta Carol, Marta Díaz, Alba|||0000-0002-0456-7085 Detlefsen, Sönke Torán-Monserrat, Pere|||0000-0002-9865-7427 Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael|||0000-0002-4485-8856 de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando|||0000-0002-9027-1263 Arslanow, Anita Korenjak, Marko|||0000-0003-4024-677X van Kleef, Laurens Falcó, Josep Lluis Kamath, P.S.|||0000-0002-7888-1165 Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander|||0000-0002-9598-4932 Ginès, Pere|||0000-0003-4657-4504 |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Angeli, Paolo|||0000-0002-1913-0716 Arslanow, Anita Caballería, Llorenç|||0000-0002-7990-0719 Carol, Marta Castera, Laurent Cucchietti, Fernando|||0000-0002-9027-1263 Detlefsen, Sönke Díaz, Alba|||0000-0002-0456-7085 Fabrellas, Núria|||0000-0001-6720-0291 Falcó, Josep Lluis Fournier, Céline Fuentes, Matilde Garcia-Retortillo, M.|||0000-0001-6783-7604 Ginès, Pere|||0000-0003-4657-4504 Graupera, Isabel|||0000-0001-9170-9784 Grgurevic, Ivica Guha, Indra Neil Hernández, Rosario Hoyo, Jordi Juan, Marta Juanola, Adrià|||0000-0003-4832-5130 Kamath, P.S.|||0000-0002-7888-1165 Karlsen, Tom H. Korenjak, Marko|||0000-0003-4024-677X Krag, Aleksander|||0000-0002-9598-4932 Lammert, Frank Llorca, Anne Ma, Ann T.|||0000-0002-9059-111X Madir, Anita Manns, Michael|||0000-0002-4485-8856 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Newsome, Phillip N. Pericàs, Juan M.|||0000-0002-3645-3293 Pich, Judit Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Serra-Burriel, Feliu Serra-Burriel, Miquel Soria, Anna|||0000-0001-5671-8343 Thiele, Maja Torán-Monserrat, Pere|||0000-0002-9865-7427 Tsochatzis, Emmanuel A. de Knegt, Robert J. de Koning, Harry J. van Kleef, Laurens |
| author_facet | Graupera, Isabel|||0000-0001-9170-9784 Thiele, Maja Ma, Ann T.|||0000-0002-9059-111X Serra-Burriel, Miquel Pich, Judit Fabrellas, Núria|||0000-0001-6720-0291 Caballería, Llorenç|||0000-0002-7990-0719 de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M.|||0000-0002-3645-3293 Angeli, Paolo|||0000-0002-1913-0716 Tsochatzis, Emmanuel A. Guha, Indra Neil Garcia-Retortillo, M.|||0000-0001-6783-7604 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola, Adrià|||0000-0003-4832-5130 Soria, Anna|||0000-0001-5671-8343 Juan, Marta Carol, Marta Díaz, Alba|||0000-0002-0456-7085 Detlefsen, Sönke Torán-Monserrat, Pere|||0000-0002-9865-7427 Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael|||0000-0002-4485-8856 de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando|||0000-0002-9027-1263 Arslanow, Anita Korenjak, Marko|||0000-0003-4024-677X van Kleef, Laurens Falcó, Josep Lluis Kamath, P.S.|||0000-0002-7888-1165 Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander|||0000-0002-9598-4932 Ginès, Pere|||0000-0003-4657-4504 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. This study is registered on (). The online version contains supplementary material available at 10.1186/s12889-022-13724-6. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_097fe82f34b4c3c97e8984bddc14e4a1 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:282714 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | LiverScreen project study protocol for screening for liver fibrosis in the general population in European countries Graupera, Isabel|||0000-0001-9170-9784 Thiele, Maja Ma, Ann T.|||0000-0002-9059-111X Serra-Burriel, Miquel Pich, Judit Fabrellas, Núria|||0000-0001-6720-0291 Caballería, Llorenç|||0000-0002-7990-0719 de Knegt, Robert J. Grgurevic, Ivica Reichert, Mathias Roulot, Dominique Schattenberg, Jörn M. Pericàs, Juan M.|||0000-0002-3645-3293 Angeli, Paolo|||0000-0002-1913-0716 Tsochatzis, Emmanuel A. Guha, Indra Neil Garcia-Retortillo, M.|||0000-0001-6783-7604 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Hernández, Rosario Hoyo, Jordi Fuentes, Matilde Madir, Anita Juanola, Adrià|||0000-0003-4832-5130 Soria, Anna|||0000-0001-5671-8343 Juan, Marta Carol, Marta Díaz, Alba|||0000-0002-0456-7085 Detlefsen, Sönke Torán-Monserrat, Pere|||0000-0002-9865-7427 Fournier, Céline Llorca, Anne Newsome, Phillip N. Manns, Michael|||0000-0002-4485-8856 de Koning, Harry J. Serra-Burriel, Feliu Cucchietti, Fernando|||0000-0002-9027-1263 Arslanow, Anita Korenjak, Marko|||0000-0003-4024-677X van Kleef, Laurens Falcó, Josep Lluis Kamath, P.S.|||0000-0002-7888-1165 Karlsen, Tom H. Castera, Laurent Lammert, Frank Krag, Aleksander|||0000-0002-9598-4932 Ginès, Pere|||0000-0003-4657-4504 Cirrhosis Screening Liver fibrosis Chronic liver disease NAFLD NASH Vibration-controlled transient elastography The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. This study is registered on (). The online version contains supplementary material available at 10.1186/s12889-022-13724-6. https://ddd.uab.cat/record/282714 https://dx.doi.org/urn:doi:10.1186/s12889-022-13724-6 |
| spellingShingle | LiverScreen project Graupera, Isabel|||0000-0001-9170-9784 Cirrhosis Screening Liver fibrosis Chronic liver disease NAFLD NASH Vibration-controlled transient elastography |
| title | LiverScreen project |
| title_full | LiverScreen project |
| title_fullStr | LiverScreen project |
| title_full_unstemmed | LiverScreen project |
| title_short | LiverScreen project |
| title_sort | LiverScreen project |
| topic | Cirrhosis Screening Liver fibrosis Chronic liver disease NAFLD NASH Vibration-controlled transient elastography |
| topic_facet | Cirrhosis Screening Liver fibrosis Chronic liver disease NAFLD NASH Vibration-controlled transient elastography |
| url | https://ddd.uab.cat/record/282714 https://dx.doi.org/urn:doi:10.1186/s12889-022-13724-6 |