Coordination of cell proliferation with developmental programs in Arabidopsis
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022
| Author: | |
|---|---|
| Format: | Doctoral thesis |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:repositorio.uam.es:10486/703839 |
| Online Access: | http://hdl.handle.net/10486/703839 |
| Access Level: | Open access |
| Keyword: | Arabidopsis thaliana Biología y Biomedicina / Biología |
| _version_ | 1878729381479710720 |
|---|---|
| author | Echevarría Zomeño, Clara |
| author_browse | Echevarría Zomeño, Clara |
| author_facet | Echevarría Zomeño, Clara |
| author_role | author |
| collection | Biblos-e Archivo. Repositorio Institucional de la UAM |
| description | Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022 |
| eu_rights_str_mv | openAccess |
| format | doctoralThesis |
| id | ES_06cfd3dd8a04503dcdee72f7ebb4c0f8 |
| institution | Universidad Autónoma de Madrid |
| instname_str | Universidad Autónoma de Madrid |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.uam.es:10486/703839 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Biblos-e Archivo. Repositorio Institucional de la UAM |
| spelling | Coordination of cell proliferation with developmental programs in Arabidopsis Coordinación de la proliferación celular con programas del desarrollo en Arabidopsis Echevarría Zomeño, Clara Arabidopsis thaliana Biología y Biomedicina / Biología Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 07-06-2022 Postembryonic development in plants constitutes a unique situation to study how the behavior of different cell types is coordinated to form all organs continuously throughout the life of the organism. Specifically, the Arabidopsis root apical meristem (RAM) is an organ, rich in proliferating cells of few cell types organized in concentric layers and with a gradual longitudinal transition from stem cells to differentiated tissues. Using a three-color cell cycle marker developed in our laboratory alongside other experimental strategies, we have begun to characterize cell cycle dynamics in the RAM. We have found that the total cell cycle length and also individual phases change depending on the tissue layers and, most notably, throughout the developmental trajectory. The G1 duration can vary between 1-2 hours in cells about to leave the root meristem and more than 20 hours in cells close to the stem cell niche, following a proximal-distal gradient that coincides with concentrations of the well-known stem cell regulator PLETHORA (PLT). Here, we have uncovered a link between developmental cues and cell cycle genes. In the regulatory network proposed, PLT proteins act upon RETINOBLASTOMA RELATED 1 (RBR1) phosphorylation by the CDK inhibitor KRP5, lengthening G1 duration by inhibiting G1/S transition http://hdl.handle.net/10486/703839 |
| spellingShingle | Coordination of cell proliferation with developmental programs in Arabidopsis Echevarría Zomeño, Clara Arabidopsis thaliana Biología y Biomedicina / Biología |
| title | Coordination of cell proliferation with developmental programs in Arabidopsis |
| title_full | Coordination of cell proliferation with developmental programs in Arabidopsis |
| title_fullStr | Coordination of cell proliferation with developmental programs in Arabidopsis |
| title_full_unstemmed | Coordination of cell proliferation with developmental programs in Arabidopsis |
| title_short | Coordination of cell proliferation with developmental programs in Arabidopsis |
| title_sort | Coordination of cell proliferation with developmental programs in Arabidopsis |
| topic | Arabidopsis thaliana Biología y Biomedicina / Biología |
| topic_facet | Arabidopsis thaliana Biología y Biomedicina / Biología |
| url | http://hdl.handle.net/10486/703839 |