Propagation of Tau via extracellular vesicles
Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s d...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:repositorio.uam.es:10486/709957 |
| Online Access: | http://hdl.handle.net/10486/709957 https://dx.doi.org/10.3389/fnins.2019.00698 |
| Access Level: | Open access |
| Keyword: | Tau propagation extracellular vesicles neurodegenerative disease Tau protein Alzheimer’s disease Medicina |
| _version_ | 1878729127025967104 |
|---|---|
| author | Pérez Martínez, María Mar |
| author2 | Avila, Jesús Hernández Pérez, Félix |
| author2_role | author author |
| author_browse | Avila, Jesús Hernández Pérez, Félix Pérez Martínez, María Mar |
| author_facet | Pérez Martínez, María Mar Avila, Jesús Hernández Pérez, Félix |
| author_role | author |
| collection | Biblos-e Archivo. Repositorio Institucional de la UAM |
| description | Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and prion diseases. All of these disorders are characterized by protein aggregation and deposition in specific regions of the brain. Several lines of evidence indicate that protein in exosomes is released from affected neurons and propagated along neuroanatomically connected regions of the brain, thus spreading the neurodegenerative disease. Also, different cell types contribute to the progression of tauopathy, such as microglia. Several groups have reported tau release via exosomes by cultured neurons or cells overexpressing human tau. Although the exact mechanisms underlying the propagation of protein aggregates are not fully understood, recent findings have implicated EVs in this process. The AD brain has two hallmarks, namely the presence of amyloid-β-containing plaques and neurofibrillary tangles, the latter formed by hyperphosphorylated tau protein. Both amyloid peptide and tau protein are present in specific exosomes. This review summarizes recent advances in our understanding of exosomes in the pathology of AD, with a special focus on tau protein |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_01fc8d36d2633f0bc2ef74134e9fa55e |
| institution | Universidad Autónoma de Madrid |
| instname_str | Universidad Autónoma de Madrid |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.uam.es:10486/709957 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| reponame_str | Biblos-e Archivo. Repositorio Institucional de la UAM |
| spelling | Propagation of Tau via extracellular vesicles Pérez Martínez, María Mar Avila, Jesús Hernández Pérez, Félix Tau propagation extracellular vesicles neurodegenerative disease Tau protein Alzheimer’s disease Medicina Extracellular vesicles (EVs), like exosomes, play a critical role in physiological processes, including synaptic transmission and nerve regeneration. However, exosomes in particular can also contribute to the development of neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and prion diseases. All of these disorders are characterized by protein aggregation and deposition in specific regions of the brain. Several lines of evidence indicate that protein in exosomes is released from affected neurons and propagated along neuroanatomically connected regions of the brain, thus spreading the neurodegenerative disease. Also, different cell types contribute to the progression of tauopathy, such as microglia. Several groups have reported tau release via exosomes by cultured neurons or cells overexpressing human tau. Although the exact mechanisms underlying the propagation of protein aggregates are not fully understood, recent findings have implicated EVs in this process. The AD brain has two hallmarks, namely the presence of amyloid-β-containing plaques and neurofibrillary tangles, the latter formed by hyperphosphorylated tau protein. Both amyloid peptide and tau protein are present in specific exosomes. This review summarizes recent advances in our understanding of exosomes in the pathology of AD, with a special focus on tau protein This study was funded by grants from Spanish Ministry of Science, Innovation and Universities (BFU2016- 77885-P), the Comunidad de Madrid, through EU structural funds (S2017/BMD-3700 NEUROMETAD-CM), CIBERNED (ISCIII), and the Fundacion Ramon Areces Frontiers Media http://hdl.handle.net/10486/709957 https://dx.doi.org/10.3389/fnins.2019.00698 |
| spellingShingle | Propagation of Tau via extracellular vesicles Pérez Martínez, María Mar Tau propagation extracellular vesicles neurodegenerative disease Tau protein Alzheimer’s disease Medicina |
| title | Propagation of Tau via extracellular vesicles |
| title_full | Propagation of Tau via extracellular vesicles |
| title_fullStr | Propagation of Tau via extracellular vesicles |
| title_full_unstemmed | Propagation of Tau via extracellular vesicles |
| title_short | Propagation of Tau via extracellular vesicles |
| title_sort | Propagation of Tau via extracellular vesicles |
| topic | Tau propagation extracellular vesicles neurodegenerative disease Tau protein Alzheimer’s disease Medicina |
| topic_facet | Tau propagation extracellular vesicles neurodegenerative disease Tau protein Alzheimer’s disease Medicina |
| url | http://hdl.handle.net/10486/709957 https://dx.doi.org/10.3389/fnins.2019.00698 |