Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials
Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in seve...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2015 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/26160 |
| Online Access: | http://hdl.handle.net/10230/26160 http://dx.doi.org/10.1016/j.neuroimage.2015.03.037 |
| Access Level: | Open access |
| Keyword: | Brain states Connectivity Anesthesia levels Default-mode network Alpha rhythm Gamma rhythm |
| _version_ | 1878729058443853824 |
|---|---|
| author | Bettinardi, Ruggero G. |
| author2 | Tort-Colet, Núria Ruiz Mejias, Marcel Sanchez-Vives, Maria V. Deco, Gustavo |
| author2_role | author author author author |
| author_browse | Bettinardi, Ruggero G. Deco, Gustavo Ruiz Mejias, Marcel Sanchez-Vives, Maria V. Tort-Colet, Núria |
| author_facet | Bettinardi, Ruggero G. Tort-Colet, Núria Ruiz Mejias, Marcel Sanchez-Vives, Maria V. Deco, Gustavo |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in several neurobiological disorders. In the present study, we induced a deep state of anesthesia in rats by means of a ketamine/medetomidine peritoneal injection, and analyzed the time course of the correlation between the brain activity in different areas while anesthesia spontaneously decreased over time. We compared results separately obtained from fMRI and local field potentials (LFPs) under the same anesthesia protocol, finding that while most profound phases of anesthesia can be described by overall sparse connectivity, stereotypical activity and poor functional integration, during lighter states different frequency-specific functional networks emerge, endowing the gradual restoration of structured large-scale activity seen during rest. Noteworthy, our in vivo results show that those areas belonging to the same functional network (the default-mode) exhibited sustained correlated oscillations around 10 Hz throughout the protocol, suggesting the presence of a specific functional backbone that is preserved even during deeper phases of anesthesia. Finally, the overall pattern of results obtained from both imaging and in vivo-recordings suggests that the progressive emergence from deep anesthesia is reflected by a corresponding gradual increase of organized correlated oscillations across the cortex. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_00a7e54d90a638c2c2dd0295e72d5b0b |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/26160 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials Bettinardi, Ruggero G. Tort-Colet, Núria Ruiz Mejias, Marcel Sanchez-Vives, Maria V. Deco, Gustavo Brain states Connectivity Anesthesia levels Default-mode network Alpha rhythm Gamma rhythm Intrinsic brain activity is characterized by the presence of highly structured networks of correlated fluctuations between different regions of the brain. Such networks encompass different functions, whose properties are known to be modulated by the ongoing global brain state and are altered in several neurobiological disorders. In the present study, we induced a deep state of anesthesia in rats by means of a ketamine/medetomidine peritoneal injection, and analyzed the time course of the correlation between the brain activity in different areas while anesthesia spontaneously decreased over time. We compared results separately obtained from fMRI and local field potentials (LFPs) under the same anesthesia protocol, finding that while most profound phases of anesthesia can be described by overall sparse connectivity, stereotypical activity and poor functional integration, during lighter states different frequency-specific functional networks emerge, endowing the gradual restoration of structured large-scale activity seen during rest. Noteworthy, our in vivo results show that those areas belonging to the same functional network (the default-mode) exhibited sustained correlated oscillations around 10 Hz throughout the protocol, suggesting the presence of a specific functional backbone that is preserved even during deeper phases of anesthesia. Finally, the overall pattern of results obtained from both imaging and in vivo-recordings suggests that the progressive emergence from deep anesthesia is reflected by a corresponding gradual increase of organized correlated oscillations across the cortex. The research reported herein was supported by the ERC Advanced Grant DYSTRUCTURE (No. 295129), FET Flagship Human Brain Project, Brain Network Recovery Group through the James S. McDonnell Foundation (220020255), FP7-ICT BrainScales (No. 269921), CORONET (No. 269459), Ministerio de Economia y Competitividad (MINECO-PSI2013-42091-P), and Agència Gestió d'Ajuts Universitaris i de Recerca (2009SGR292) to G.D. M.V.S.V. was supported by the Ministerio de Economía y Competitividad (Spain)BFU2011-27094 and EU project CORTICONIC Contract number 600806. Elsevier http://hdl.handle.net/10230/26160 http://dx.doi.org/10.1016/j.neuroimage.2015.03.037 |
| spellingShingle | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials Bettinardi, Ruggero G. Brain states Connectivity Anesthesia levels Default-mode network Alpha rhythm Gamma rhythm |
| status_str | publishedVersion |
| title | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| title_full | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| title_fullStr | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| title_full_unstemmed | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| title_short | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| title_sort | Gradual emergence of spontaneous correlated brain activity during fading of general anesthesia in rats: Evidences from fMRI and local field potentials |
| topic | Brain states Connectivity Anesthesia levels Default-mode network Alpha rhythm Gamma rhythm |
| topic_facet | Brain states Connectivity Anesthesia levels Default-mode network Alpha rhythm Gamma rhythm |
| url | http://hdl.handle.net/10230/26160 http://dx.doi.org/10.1016/j.neuroimage.2015.03.037 |