Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health»
Heavy metal contamination in agricultural soils has emerged as a critical environmental and public health issue associated with increased gastric cancer incidence worldwide. Among the most concerning pollutants are cadmium, arsenic, and lead, which persist in the environment and enter the human body...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2026 |
| Country: | Ecuador |
| Institution: | PUCE |
| Repository: | Repositorio Pontificia Universidad Católica del Ecuador |
| OAI Identifier: | oai:repositorio.puce.edu.ec:123456789/49172 |
| Online Access: | https://doi.org/10.3390/ijms262311526 https://www.mdpi.com/1422-0067/26/23/11526 https://repositorio.puce.edu.ec/handle/123456789/49172 |
| Access Level: | Open access |
| Keyword: | Cadmium Heavy metals Gastric cancer Arsenic Lead Environmental contamination One Health |
| _version_ | 1878406849142718464 |
|---|---|
| author | Reytor González , Claudia Leyva |
| author2 | Ricardo Sonia , Emilia Sánchez Suárez , Yasniel Burboa Charis , Vianey Ariadna Jiménez Flores , Emilia Cevallos Fernández , Emilia Luciana Campuzano Donoso, Martín Simancas Racines, Daniel Alejandro |
| author2_role | author author author author author author author |
| author_browse | Burboa Charis , Vianey Ariadna Campuzano Donoso, Martín Cevallos Fernández , Emilia Luciana Jiménez Flores , Emilia Reytor González , Claudia Leyva Ricardo Sonia , Emilia Simancas Racines, Daniel Alejandro Sánchez Suárez , Yasniel |
| author_facet | Reytor González , Claudia Leyva Ricardo Sonia , Emilia Sánchez Suárez , Yasniel Burboa Charis , Vianey Ariadna Jiménez Flores , Emilia Cevallos Fernández , Emilia Luciana Campuzano Donoso, Martín Simancas Racines, Daniel Alejandro |
| author_role | author |
| collection | Repositorio Pontificia Universidad Católica del Ecuador |
| description | Heavy metal contamination in agricultural soils has emerged as a critical environmental and public health issue associated with increased gastric cancer incidence worldwide. Among the most concerning pollutants are cadmium, arsenic, and lead, which persist in the environment and enter the human body primarily through the soil–plant–food chain. This review integrates environmental, molecular, and epidemiological evidence to explain how these metals alter gastric mucosal biology and promote carcinogenesis. Mechanistically, cadmium, arsenic, and lead trigger oxidative stress, mitochondrial dysfunction, DNA damage, and epigenetic reprogramming, resulting in genomic instability, resistance to programmed cell death, and the transformation of epithelial cells into invasive phenotypes. These molecular disruptions interact with Helicobacter pylori infection, microbial imbalance, chronic inflammation, and hypoxia-driven remodeling of the gastric stroma, all of which enhance angiogenesis and tumor progression. Advanced experimental platforms, such as gastric organoids, immune co-cultures, and humanized animal models, are improving the understanding of these complex interactions. Adopting a One Health perspective reveals the continuity between environmental contamination, agricultural production, and human disease, underscoring the importance of integrative monitoring systems that combine soil and crop analysis with molecular biomarkers in exposed populations. Strengthening this interdisciplinary approach is essential to design preventive strategies, guide remediation policies, and protect human, animals, and environmental health. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | EC_8d3f063d7c34fd0490dc9c07f58c83ff |
| identifier_str_mv | " Reytor-González, C.; Leyva Ricardo, S.E.; Sánchez Suárez, Y.;Burboa Charis, V.A.; Jiménez-Flores, E.; Cevallos-Fernández, E.;Campuzano-Donoso, M.; SimancasRacines, D. Heavy Metal Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective. Int. J. Mol. Sci. 2025, 26,11526. https://doi.org/10.3390/ ijms262311526" 1422-0067 |
| institution | PUCE |
| instname_str | Pontificia Universidad Católica del Ecuador |
| network_acronym_str | EC |
| network_name_str | Ecuador |
| oai_identifier_str | oai:repositorio.puce.edu.ec:123456789/49172 |
| publishDate | 2026 |
| publishDateSort | 2026 |
| reponame_str | Repositorio Pontificia Universidad Católica del Ecuador |
| spelling | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» Heavy metal-contaminated soils and gastric cancer risk: molecular insights and the relevance of a one health perspective Reytor González , Claudia Leyva Ricardo Sonia , Emilia Sánchez Suárez , Yasniel Burboa Charis , Vianey Ariadna Jiménez Flores , Emilia Cevallos Fernández , Emilia Luciana Campuzano Donoso, Martín Simancas Racines, Daniel Alejandro Cadmium Heavy metals Gastric cancer Arsenic Lead Environmental contamination One Health Heavy metal contamination in agricultural soils has emerged as a critical environmental and public health issue associated with increased gastric cancer incidence worldwide. Among the most concerning pollutants are cadmium, arsenic, and lead, which persist in the environment and enter the human body primarily through the soil–plant–food chain. This review integrates environmental, molecular, and epidemiological evidence to explain how these metals alter gastric mucosal biology and promote carcinogenesis. Mechanistically, cadmium, arsenic, and lead trigger oxidative stress, mitochondrial dysfunction, DNA damage, and epigenetic reprogramming, resulting in genomic instability, resistance to programmed cell death, and the transformation of epithelial cells into invasive phenotypes. These molecular disruptions interact with Helicobacter pylori infection, microbial imbalance, chronic inflammation, and hypoxia-driven remodeling of the gastric stroma, all of which enhance angiogenesis and tumor progression. Advanced experimental platforms, such as gastric organoids, immune co-cultures, and humanized animal models, are improving the understanding of these complex interactions. Adopting a One Health perspective reveals the continuity between environmental contamination, agricultural production, and human disease, underscoring the importance of integrative monitoring systems that combine soil and crop analysis with molecular biomarkers in exposed populations. Strengthening this interdisciplinary approach is essential to design preventive strategies, guide remediation policies, and protect human, animals, and environmental health. " Reytor-González, C.; Leyva Ricardo, S.E.; Sánchez Suárez, Y.;Burboa Charis, V.A.; Jiménez-Flores, E.; Cevallos-Fernández, E.;Campuzano-Donoso, M.; SimancasRacines, D. Heavy Metal Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective. Int. J. Mol. Sci. 2025, 26,11526. https://doi.org/10.3390/ ijms262311526" 1422-0067 https://doi.org/10.3390/ijms262311526 https://www.mdpi.com/1422-0067/26/23/11526 https://repositorio.puce.edu.ec/handle/123456789/49172 |
| spellingShingle | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» Reytor González , Claudia Leyva Cadmium Heavy metals Gastric cancer Arsenic Lead Environmental contamination One Health |
| status_str | publishedVersion |
| title | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| title_full | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| title_fullStr | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| title_full_unstemmed | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| title_short | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| title_sort | Suelos contaminados con metales pesados y riesgo de cáncer gástrico Perspectivas moleculares y la relevancia de una perspectiva de «One Health» |
| topic | Cadmium Heavy metals Gastric cancer Arsenic Lead Environmental contamination One Health |
| topic_facet | Cadmium Heavy metals Gastric cancer Arsenic Lead Environmental contamination One Health |
| url | https://doi.org/10.3390/ijms262311526 https://www.mdpi.com/1422-0067/26/23/11526 https://repositorio.puce.edu.ec/handle/123456789/49172 |