Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom
The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2001 |
| Country: | Costa Rica |
| Institution: | UCR |
| Repository: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/29476 |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0041010100002543 https://hdl.handle.net/10669/29476 |
| Access Level: | Embargoed access |
| Keyword: | Bothrops asper venom Hyperalgesia Bradykinin Leukotrienes Snake venom |
| _version_ | 1878655259571650560 |
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| author | Chacur, Marucia |
| author2 | Picolo, Gisele Gutiérrez, José María Teixeira, Catarina de Fátima Cury, Yara |
| author2_role | author author author author |
| author_browse | Chacur, Marucia Cury, Yara Gutiérrez, José María Picolo, Gisele Teixeira, Catarina de Fátima |
| author_facet | Chacur, Marucia Picolo, Gisele Gutiérrez, José María Teixeira, Catarina de Fátima Cury, Yara |
| author_role | author |
| bitstream_url_str_mv | https://www.kerwa.ucr.ac.cr/bitstreams/5fd3ccae-a91e-4d8c-9b0a-2974f2514a06/download https://www.kerwa.ucr.ac.cr/bitstreams/4af7c6ed-6efb-4ab1-8843-11431a5258e6/download https://www.kerwa.ucr.ac.cr/bitstreams/505f7db6-2a27-499a-b338-66f0eea14fcb/download https://www.kerwa.ucr.ac.cr/bitstreams/a987ad17-4564-4a41-b47b-b1580c011fe5/download |
| collection | Kérwá |
| description | The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B2 receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A2. Inhibition of the lipoxygenase pathway by NDGA abrogated the algogenic phenomenon. The hyperalgesic response was not modified by pretreatment with indomethacin, an inhibitor of the cyclo-oxygenase pathway, by meloxicam, an inhibitor of the type 2 cyclo-oxygenase pathway, by the PAF receptor antagonist BN52021 or by anti-TNF-α or anti-interleukin 1 antibodies. Intraplantar injection of the venom also caused an oedematogenic response which was not modified by any of these pharmacological treatments. These results suggest that hyperalgesia induced by Bothrops asper venom is, at least partially, mediated by bradykinin, phospholipase A2 activity and leukotrienes. Distinct mechanisms are involved in the development of hyperalgesia and oedema induced by the venom. |
| eu_rights_str_mv | embargoedAccess |
| format | article |
| id | CR_96d6500a8fe9bd1b3f4c77cd1c1efcda |
| identifier_str_mv | 10.1016/S0041-0101(00)00254-3 |
| institution | UCR |
| instname_str | Universidad de Costa Rica |
| network_acronym_str | CR |
| network_name_str | Costa Rica |
| oai_identifier_str | oai:kerwa.ucr.ac.cr:10669/29476 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| reponame_str | Kérwá |
| spelling | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom Chacur, Marucia Picolo, Gisele Gutiérrez, José María Teixeira, Catarina de Fátima Cury, Yara Bothrops asper venom Hyperalgesia Bradykinin Leukotrienes Snake venom The ability of Bothrops asper snake venom to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of the venom (5–15 μg/paw) caused a dose and time-related hyperalgesia, which peaked 2 h after venom injection. Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B2 receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A2. Inhibition of the lipoxygenase pathway by NDGA abrogated the algogenic phenomenon. The hyperalgesic response was not modified by pretreatment with indomethacin, an inhibitor of the cyclo-oxygenase pathway, by meloxicam, an inhibitor of the type 2 cyclo-oxygenase pathway, by the PAF receptor antagonist BN52021 or by anti-TNF-α or anti-interleukin 1 antibodies. Intraplantar injection of the venom also caused an oedematogenic response which was not modified by any of these pharmacological treatments. These results suggest that hyperalgesia induced by Bothrops asper venom is, at least partially, mediated by bradykinin, phospholipase A2 activity and leukotrienes. Distinct mechanisms are involved in the development of hyperalgesia and oedema induced by the venom. Fundação de Amparo à Pesquisa do Estado de São Paulo/[98/00257-0]/FAPESP/Brasil Instituto Butantan///Brasil Universidad de Costa Rica//UCR/Costa Rica UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) http://www.sciencedirect.com/science/article/pii/S0041010100002543 0041-0101 https://hdl.handle.net/10669/29476 10.1016/S0041-0101(00)00254-3 11306127 |
| spellingShingle | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom Chacur, Marucia Bothrops asper venom Hyperalgesia Bradykinin Leukotrienes Snake venom |
| title | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| title_full | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| title_fullStr | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| title_full_unstemmed | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| title_short | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| title_sort | Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom |
| topic | Bothrops asper venom Hyperalgesia Bradykinin Leukotrienes Snake venom |
| topic_facet | Bothrops asper venom Hyperalgesia Bradykinin Leukotrienes Snake venom |
| url | http://www.sciencedirect.com/science/article/pii/S0041010100002543 https://hdl.handle.net/10669/29476 |