Co-Infection with Cryptosporidium meleagridis and Enterocytozoon bieneusi in an HIV+ Colombian Patient
ABSTRACT: A 44-year-old human immunodeficiency virus-infected (HIV+) female with severe immunodeficiency Category 3 (C3) diagnosed in 2010 was admitted to hospital with acute diarrhoea. She was non-adherent to antiretroviral therapy (ART) and had a previous suspicion of respiratory symptoms with a c...
| Autores: | ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2023 |
| País: | Colombia |
| Institución: | Universidad de Antioquia |
| Repositorio: | Repositorio UdeA |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:bibliotecadigital.udea.edu.co:10495/44127 |
| Acceso en línea: | https://hdl.handle.net/10495/44127 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Infecciones Oportunistas Opportunistic Infections Cryptosporidium Huésped Inmunocomprometido Immunocompromised Host Síndrome de Inmunodeficiencia Adquirida Acquired Immunodeficiency Syndrome VIH HIV Enterocytozoon Medellín (Colombia) https://id.nlm.nih.gov/mesh/D009894 https://id.nlm.nih.gov/mesh/D003458 https://id.nlm.nih.gov/mesh/D016867 https://id.nlm.nih.gov/mesh/D000163 https://id.nlm.nih.gov/mesh/D006678 https://id.nlm.nih.gov/mesh/D021862 |
| Sumario: | ABSTRACT: A 44-year-old human immunodeficiency virus-infected (HIV+) female with severe immunodeficiency Category 3 (C3) diagnosed in 2010 was admitted to hospital with acute diarrhoea. She was non-adherent to antiretroviral therapy (ART) and had a previous suspicion of respiratory symptoms with a cough that had been persisting for 15 days. Clinical examination revealed severe immune deterioration (viral load: 109,655 copies/mL; CD4+ count: 14 cells/mm3), respiratory symptoms (negative sputum Gram stain and tuberculosis culture), and neurological deterioration (serological assays negative for Cryptococcus spp. and Toxoplasma gondii). A coproculture was negative for Campylobacter spp., Salmonella spp., and Shigella spp. Ziehl–Neelsen staining of faecal smears revealed the presence of Cryptosporidium spp. oocysts. PCR testing and sequencing confirmed a concomitant infection with C. meleagridis and Enterocytozoon bieneusi. The patient was treated with metronidazole (500 mg every 8 h for 5 days) and nitazoxanide (500 mg every 12 h for 14 days). After requesting voluntary discharge and abandoning ART and parasiticidal treatments, she experienced a dramatic deterioration of her state of health and contact with her was lost. Our results have demonstrated that molecular-based testing improves the detection of opportunistic pathogens that are difficult to detect by routine microscopy, allows for transmission dynamics investigations, and assists in choosing the best chemotherapeutical option. |
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