SYNTHESIS OF 3 SUBSTITUTED ISOQUINOLIN-1-YL-2-(CYCLOALK-2-ENYLIDENE) HYDRAZINES AND THEIR ANTIMICROBIAL PROPERTIES
New hydrazine derivatives were synthesized via reaction between 1, 3 cyclic diketones and hydrazinoisoquinohne derivatives. The reaction proceeded smoothly in ethanol under reflux temperature and furnished products in excellent yields (76-87%). The products have been purified and fully characterized...
| Autores: | ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Estado: | Published version |
| Data de publicação: | 2009 |
| País: | Chile |
| Recursos: | Agencia Nacional de Investigación y Desarrollo |
| Repositório: | SciELO Chile |
| Idioma: | Inglês |
| OAI Identifier: | oai:scielo:S0717-97072009000200020 |
| Acesso em linha: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200020 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | 1, 3-cyclic diketones hydrazinoisoquinohne derivatives |
| Resumo: | New hydrazine derivatives were synthesized via reaction between 1, 3 cyclic diketones and hydrazinoisoquinohne derivatives. The reaction proceeded smoothly in ethanol under reflux temperature and furnished products in excellent yields (76-87%). The products have been purified and fully characterized by spectroscopy techniques. The compounds 8a-c showed good bacterial inhibition against Bacillus cerus and 8d-f showed good antifungal activity against Candida albicans. |
|---|