Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones
In this study, we report the synthesis and characterization of eight new palladium complexes and a nickel complex containing thiosemicarbazone ligands derived from chalcones and benzalketones. The techniques of Infrared and UV–visible spectroscopy, Nuclear Magnetic Resonance, Mass Spectrometry, and...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artigo |
| Estado: | Published version |
| Data de publicação: | 2024 |
| País: | Brasil |
| Recursos: | UNESP |
| Repositório: | Repositório Institucional da UNESP |
| Idioma: | Inglês |
| OAI Identifier: | oai:repositorio.unesp.br:11449/302176 |
| Acesso em linha: | http://dx.doi.org/10.1016/j.poly.2024.117021 https://hdl.handle.net/11449/302176 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | ct-DNA Cytotoxicity Nickel(II) Palladium(II) Thiosemicarbazone Topoisomerase |
| _version_ | 1878766297506906112 |
|---|---|
| author | Thayane Paes Silva, Ludimila |
| author2 | Bueno Santana Pereira, George Porto de Oliveira, Gabriela Almeida Lima, Mauro Honorato de Araujo-Neto, João Olalekan Akinyemi, Amos Alcântara Vieira, Marcelle [UNESP] Monteiro Nascimento-Júnior, Nailton [UNESP] Lira de Farias, Renan Alcides Ellena, Javier Vieira de Godoy Netto, Adelino [UNESP] Vieira Rocha, Fillipe |
| author2_role | author author author author author author author author author author author |
| author_browse | Alcides Ellena, Javier Alcântara Vieira, Marcelle [UNESP] Almeida Lima, Mauro Bueno Santana Pereira, George Honorato de Araujo-Neto, João Lira de Farias, Renan Monteiro Nascimento-Júnior, Nailton [UNESP] Olalekan Akinyemi, Amos Porto de Oliveira, Gabriela Thayane Paes Silva, Ludimila Vieira Rocha, Fillipe Vieira de Godoy Netto, Adelino [UNESP] |
| author_facet | Thayane Paes Silva, Ludimila Bueno Santana Pereira, George Porto de Oliveira, Gabriela Almeida Lima, Mauro Honorato de Araujo-Neto, João Olalekan Akinyemi, Amos Alcântara Vieira, Marcelle [UNESP] Monteiro Nascimento-Júnior, Nailton [UNESP] Lira de Farias, Renan Alcides Ellena, Javier Vieira de Godoy Netto, Adelino [UNESP] Vieira Rocha, Fillipe |
| author_role | author |
| collection | Repositório Institucional da UNESP |
| description | In this study, we report the synthesis and characterization of eight new palladium complexes and a nickel complex containing thiosemicarbazone ligands derived from chalcones and benzalketones. The techniques of Infrared and UV–visible spectroscopy, Nuclear Magnetic Resonance, Mass Spectrometry, and Elemental Analysis fully characterized the compounds. Crystallography was successful for five complexes and two ligands, allowing for X-ray Diffraction analysis. Molecular docking studies and assays involving DNA interaction via agarose gel electrophoresis and UV–Vis titration revealed no DNA interaction or inhibition of topoisomerase IIα enzyme activity. However, these compounds demonstrated potent cytotoxic effects (IC50) against breast tumor (MCF-7) and prostate (DU-145) cell lines, as well as non-tumor prostate (PNT2) cell lines. These findings highlight the relevance of structural variations and the metallic center's nature in achieving cytotoxic effects, offering insights into the development of bioactive compounds. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_e3a4620a1cf20a35cfc9b97ac4e4f97e |
| institution | UNESP |
| instname_str | Universidade Estadual Paulista (UNESP) |
| language | eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:repositorio.unesp.br:11449/302176 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Repositório Institucional da UNESP |
| spelling | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones Thayane Paes Silva, Ludimila Bueno Santana Pereira, George Porto de Oliveira, Gabriela Almeida Lima, Mauro Honorato de Araujo-Neto, João Olalekan Akinyemi, Amos Alcântara Vieira, Marcelle [UNESP] Monteiro Nascimento-Júnior, Nailton [UNESP] Lira de Farias, Renan Alcides Ellena, Javier Vieira de Godoy Netto, Adelino [UNESP] Vieira Rocha, Fillipe ct-DNA Cytotoxicity Nickel(II) Palladium(II) Thiosemicarbazone Topoisomerase In this study, we report the synthesis and characterization of eight new palladium complexes and a nickel complex containing thiosemicarbazone ligands derived from chalcones and benzalketones. The techniques of Infrared and UV–visible spectroscopy, Nuclear Magnetic Resonance, Mass Spectrometry, and Elemental Analysis fully characterized the compounds. Crystallography was successful for five complexes and two ligands, allowing for X-ray Diffraction analysis. Molecular docking studies and assays involving DNA interaction via agarose gel electrophoresis and UV–Vis titration revealed no DNA interaction or inhibition of topoisomerase IIα enzyme activity. However, these compounds demonstrated potent cytotoxic effects (IC50) against breast tumor (MCF-7) and prostate (DU-145) cell lines, as well as non-tumor prostate (PNT2) cell lines. These findings highlight the relevance of structural variations and the metallic center's nature in achieving cytotoxic effects, offering insights into the development of bioactive compounds. Departamento de Química Universidade Federal de São Carlos, SP Instituto Federal de Educação ciência e Tecnologia Baiano Campus Guanambi, BA Departamento de Química Fundamental Instituto de Química Universidade de São Paulo, SP Department of Toxicology and Cancer Biology University of Kentucky Departamento de Bioquímica e Química Orgânica Instituto de Química Universidade Estadual Paulista, SP Pontifícia Universidade Católica do Rio de Janeiro, RJ Instituto de Física de São Carlos Universidade de São Paulo, SP Departamento de Química Geral e Inorgânica Instituto de Química de Araraquara UNESP - Univ. Estadual Paulista, SP http://dx.doi.org/10.1016/j.poly.2024.117021 Polyhedron, v. 257. 0277-5387 https://hdl.handle.net/11449/302176 10.1016/j.poly.2024.117021 2-s2.0-85192262653 |
| spellingShingle | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones Thayane Paes Silva, Ludimila ct-DNA Cytotoxicity Nickel(II) Palladium(II) Thiosemicarbazone Topoisomerase |
| status_str | publishedVersion |
| title | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| title_full | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| title_fullStr | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| title_full_unstemmed | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| title_short | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| title_sort | Synthesis, characterization, cytotoxicity study, interaction with DNA and topoisomerase IIα of square-planar complexes with thiosemicarbazones |
| topic | ct-DNA Cytotoxicity Nickel(II) Palladium(II) Thiosemicarbazone Topoisomerase |
| topic_facet | ct-DNA Cytotoxicity Nickel(II) Palladium(II) Thiosemicarbazone Topoisomerase |
| url | http://dx.doi.org/10.1016/j.poly.2024.117021 https://hdl.handle.net/11449/302176 |