ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION
Hemolytic uremic syndrome (HUS) is a disease that belongs to the group of thrombotic microangiopathies1, a serious disease defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is divided into two subtypes, the typical SHU and the atypical SHU (SHUa)...
| Authors: | ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2020 |
| Country: | Brasil |
| Institution: | JRG |
| Repository: | Revista JRG de Estudos Acadêmicos |
| Language: | Portuguese English |
| OAI Identifier: | oai:ojs2.revistajrg.com:article/32 |
| Online Access: | http://revistajrg.com/index.php/jrg/article/view/32 |
| Access Level: | Open access |
| Keyword: | Síndrome Hemolítica Urêmica Atípica. Microangiopatia trombótica. Eculizumab. Atypical Hemolytic Uremic Syndrome. Thrombotic microangiopathy. Eculizumab. |
| _version_ | 1878765421516029952 |
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| author | Barbosa, Thamara Cardoso |
| author2 | Caixeta, Mariellen da Silva Santos, Walquiria Lene dos Álvares, Alice da Cunha Morales |
| author2_role | author author author |
| author_browse | Barbosa, Thamara Cardoso Caixeta, Mariellen da Silva Santos, Walquiria Lene dos Álvares, Alice da Cunha Morales |
| author_facet | Barbosa, Thamara Cardoso Caixeta, Mariellen da Silva Santos, Walquiria Lene dos Álvares, Alice da Cunha Morales |
| author_role | author |
| collection | Revista JRG de Estudos Acadêmicos |
| description | Hemolytic uremic syndrome (HUS) is a disease that belongs to the group of thrombotic microangiopathies1, a serious disease defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is divided into two subtypes, the typical SHU and the atypical SHU (SHUa). This division is based on the clinical presentation and, mainly, on the causes of the syndrome. The aim of this study was to identify cases of recurrence of Atypical Hemolytic Uremic Syndrome after Kidney Transplantation. This is an integrative review of a qualitative approach, carried out from August 2019 to June 2020. References were sought such as: Scientific Eletronic Library Online, Brazilian Journal of Nephrology, Ministry of Health, MEDLINE and BDENF, where they were researched and studied 22, of which 6 were more relevant to the development of this work. The results of the study demonstrate that although it is considered a serious disease, there are few studies carried out on HUSA, and with a long period of time between publications, however the recurrence of HUSA after renal transplantation requiring drug treatment with Eculizumab is concluded. throughout life. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_d851cd67fdf11ec6446bd791a00a2ea0 |
| institution | JRG |
| instname_str | Editora JRG |
| language | por eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:ojs2.revistajrg.com:article/32 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Editora JRG |
| publisherStr | Editora JRG |
| reponame_str | Revista JRG de Estudos Acadêmicos |
| spelling | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION SÍNDROME HEMOLÍTICA URÊMICA ATÍPICA (SHUA) PÓS TRANSPLANTE RENAL Barbosa, Thamara Cardoso Caixeta, Mariellen da Silva Santos, Walquiria Lene dos Álvares, Alice da Cunha Morales Síndrome Hemolítica Urêmica Atípica. Microangiopatia trombótica. Eculizumab. Atypical Hemolytic Uremic Syndrome. Thrombotic microangiopathy. Eculizumab. Hemolytic uremic syndrome (HUS) is a disease that belongs to the group of thrombotic microangiopathies1, a serious disease defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is divided into two subtypes, the typical SHU and the atypical SHU (SHUa). This division is based on the clinical presentation and, mainly, on the causes of the syndrome. The aim of this study was to identify cases of recurrence of Atypical Hemolytic Uremic Syndrome after Kidney Transplantation. This is an integrative review of a qualitative approach, carried out from August 2019 to June 2020. References were sought such as: Scientific Eletronic Library Online, Brazilian Journal of Nephrology, Ministry of Health, MEDLINE and BDENF, where they were researched and studied 22, of which 6 were more relevant to the development of this work. The results of the study demonstrate that although it is considered a serious disease, there are few studies carried out on HUSA, and with a long period of time between publications, however the recurrence of HUSA after renal transplantation requiring drug treatment with Eculizumab is concluded. throughout life. A síndrome hemolítica urêmica (SHU) é uma doença que pertence ao grupo das microangiopatias trombóticas1 doença esta, grave definida pela tríade de anemia hemolítica microangiopática, trombocitopenia e lesão renal aguda. É dividida em dois subtipos, a SHU típica e a SHU atípica (SHUa). Essa divisão é baseada na apresentação clínica e, principalmente, nas causas da síndrome. O objetivo deste estudo foi identificar os casos de recorrência da Síndrome Hemolítica Urêmica Atípica Pós Transplante Renal. Trata-se de uma revisão integrativa de abordagem qualitativa, realizada nos meses de agosto de 2019 a junho de 2020. Buscou-se referências como: Scientific Eletronic Library Online, Jornal Brasileiro de Nefrologia, Ministério da Saúde, MEDLINE e BDENF, onde foram pesquisados e estudados 22, dos quais 6 tiveram mais relevância para o desenvolvimento deste trabalho. Os resultados do estudo demonstram que ainda que seja considerada uma doença grave, poucos são os estudos realizados sobre SHUa, e com longo intervalo de tempo entre as publicações, contudo conclui-se a recorrência de SHUa pós transplante renal necessitando de tratamento medicamentoso com Eculizumab ao longo da vida. Editora JRG http://revistajrg.com/index.php/jrg/article/view/32 10.5281/jrg.v3i7.32 |
| spellingShingle | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION Barbosa, Thamara Cardoso Síndrome Hemolítica Urêmica Atípica. Microangiopatia trombótica. Eculizumab. Atypical Hemolytic Uremic Syndrome. Thrombotic microangiopathy. Eculizumab. |
| status_str | publishedVersion |
| title | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| title_full | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| title_fullStr | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| title_full_unstemmed | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| title_short | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| title_sort | ATYPICAL UREMIC HEMOLYTIC SYNDROME (SHUA) AFTER KIDNEY TRANSPLANTATION |
| topic | Síndrome Hemolítica Urêmica Atípica. Microangiopatia trombótica. Eculizumab. Atypical Hemolytic Uremic Syndrome. Thrombotic microangiopathy. Eculizumab. |
| topic_facet | Síndrome Hemolítica Urêmica Atípica. Microangiopatia trombótica. Eculizumab. Atypical Hemolytic Uremic Syndrome. Thrombotic microangiopathy. Eculizumab. |
| url | http://revistajrg.com/index.php/jrg/article/view/32 |