Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs
Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas a...
| Autores: | ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2012 |
| País: | Brasil |
| Institución: | UNESP |
| Repositorio: | Repositório Institucional da UNESP |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/126022 |
| Acceso en línea: | http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=25391#.Vb-hMBtVhHw http://hdl.handle.net/11449/126022 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry Vascular endothelial growth factor |
| _version_ | 1878760595372638208 |
|---|---|
| author | Campos, Andressa Gianotti |
| author2 | Campos, Juliana Alvares Duarte Bonini [UNESP] Sanches, Daniel Soares Dagli, Maria Lúcia Zaidan Matera, Julia Maria |
| author2_role | author author author author |
| author_browse | Campos, Andressa Gianotti Campos, Juliana Alvares Duarte Bonini [UNESP] Dagli, Maria Lúcia Zaidan Matera, Julia Maria Sanches, Daniel Soares |
| author_facet | Campos, Andressa Gianotti Campos, Juliana Alvares Duarte Bonini [UNESP] Sanches, Daniel Soares Dagli, Maria Lúcia Zaidan Matera, Julia Maria |
| author_role | author |
| collection | Repositório Institucional da UNESP |
| description | Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_98b186c99819942e9cee55e21d5ff4e1 |
| institution | UNESP |
| instname_str | Universidade Estadual Paulista (UNESP) |
| language | eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:repositorio.unesp.br:11449/126022 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| reponame_str | Repositório Institucional da UNESP |
| spelling | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs Campos, Andressa Gianotti Campos, Juliana Alvares Duarte Bonini [UNESP] Sanches, Daniel Soares Dagli, Maria Lúcia Zaidan Matera, Julia Maria Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry Vascular endothelial growth factor Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P < 0.05). These findings suggest the presence of high VEGF levels may be related to the malignant vascular proliferation seen in hemangiosarcomas. Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Odontologia Social, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá 1680, Centro, CEP 14801-385, SP, Brasil Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil. Department of Animal Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Brazil. http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=25391#.Vb-hMBtVhHw Open Journal of Veterinary Medicine, v. 02, n. 04, p. 191-195, 2012. 2165-3356 http://hdl.handle.net/11449/126022 10.4236/ojvm.2012.24030 7167211040669505 |
| spellingShingle | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs Campos, Andressa Gianotti Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry Vascular endothelial growth factor |
| status_str | publishedVersion |
| title | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| title_full | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| title_fullStr | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| title_full_unstemmed | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| title_short | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| title_sort | Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in splenic hemangiomas and hemangiosarcomas in dogs |
| topic | Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry Vascular endothelial growth factor |
| topic_facet | Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry Vascular endothelial growth factor |
| url | http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=25391#.Vb-hMBtVhHw http://hdl.handle.net/11449/126022 |