Effects of a sodium-free salting agent on blood hepatic, renal and cardiac biochemical markers of normal and hypertensive rats

Introduction: Hypertension is one of the risk factors for cardiovascular diseases, being directly associated with high consumption of sodium. Objective: To assess the levels of hepatic, renal and cardiac injury markers in hypertensive rats compared to their normotensive controls, treated with a salt...

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Authors: Menezes-Rodrigues, Francisco Sandro; Ferraz, Renato Ribeiro Nogueira; Oliveira, Alex Sandro Felisberto; Silva, Marcos José da; Bergantin, Leandro Bueno; Ambrósio, Ricardo Thiago Paniza; Fantoni, Alessandra de Oliveira; de Paula, Luciana; Errante, Paolo Ruggero; Serinolli, Mário Ivo; Caricati-Neto, Afonso
Format: Article
Status:Published version
Publication date:2017
Country:Brasil
Institution:UNINOVE
Repository:Revista Conscientiae Saúde (Online)
Language:Portuguese
OAI Identifier:oai:ojs.periodicos.uninove.br:article/7118
Online Access:https://periodicos.uninove.br/saude/article/view/7118
Access Level:Open access
Keyword:Hypertension
Cardiac frequency
Nutraceutical
NaCl.
Hipertensão
Frequência cardíaca
Nutracêuticos
Summary:Introduction: Hypertension is one of the risk factors for cardiovascular diseases, being directly associated with high consumption of sodium. Objective: To assess the levels of hepatic, renal and cardiac injury markers in hypertensive rats compared to their normotensive controls, treated with a salt free saline solution, water or NaCl. Methods: Hypertensive rats (SHR) and their normotensive controls (NWR) were divided into 3 groups (n = 7): G1 (water); G2 (aqueous solution containing NaCl 70 mg / kg / day); G3 (sodium salt-free aqueous solution 70 mg / kg / day). After 30 days, the animals’ blood was processed. Results: There was no difference between serum levels of total creatine kinase, creatine kinase-MB, lactate dehydrogenase, uric acid, aspartate aminotransferase and alkaline phosphatase in both NWR and SHR1 treated NaCl or Salgante. There was a decrease in creatinine in NWR and SHR treated with NaCl and Salgante comparing to controls (p <0.005). Conclusions: Daily supplementation with sodium salt-free aqueous solution and NaCl decreases serum creatinine levels in NWR and SHR groups. However, there was no change in serum levels of cardiac and hepatic injury markers.

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