Uso potencial dos anticonvulsivantes no tratamento ambulatorial da dependência de álcool

Currently three medications (disulfiram, naltrexone and acamprosate) are approved by the FDA to treat alcohol dependence by the FDA. The classical anticonvulsive drugs are rarely employed as an alternative because of their side effects, but the latest generation of anticonvulsants could be useful. T...

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Bibliographic Details
Authors: Castro, Luís André [UNIFESP]; Couzi, Carla [UNIFESP]
Format: Article
Status:Published version
Publication date:2006
Country:Brasil
Institution:UNIFESP
Repository:Repositório Institucional da UNIFESP
Language:Portuguese
OAI Identifier:oai:repositorio.unifesp.br:11600/2851
Online Access:http://dx.doi.org/10.1590/S0047-20852006000300007
http://repositorio.unifesp.br/handle/11600/2851
Access Level:Open access
Keyword:anticonvulsants
alcoholism
carbamazepine
valproic acid
anticonvulsivantes
alcoolismo
carbamazepina
ácido valpróico
Description
Summary:Currently three medications (disulfiram, naltrexone and acamprosate) are approved by the FDA to treat alcohol dependence by the FDA. The classical anticonvulsive drugs are rarely employed as an alternative because of their side effects, but the latest generation of anticonvulsants could be useful. The anticonvulsants can be a alternative to BZD and other pharmacological treatments in the prevention of complications during the detoxification therapy, because of the absence of addictive properties and a better adverse effects profile than classical anticonvulsant drugs. Anticonvulsants such as carbamazepine, valproic acid, gabapentin and topiramate have shown to be excellent treatment for alcohol withdrawal and for the prevention of alcohol relapse. Although none of these agents have been approved by the FDA yet, there is growing evidence in the literature to support their use.