Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology
Abstract In this era, various traditional medicinal herbs were researched for their toxicological and safety aspects. The present study focused on using Nigella sativa fixed (NSFO) and essential oil (NSEO) to mitigate the adverse consequences of oxidative stress. For the purpose, oxidative stress wa...
| Autores: | ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | SBCTA |
| Repositorio: | Food Science and Technology (Campinas) |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:scielo:S0101-20612021000200404 |
| Acceso en línea: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200404 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | functional foods oxidative stress N. sativa antioxidant thymoquinone |
| _version_ | 1878754398229757952 |
|---|---|
| author | Sultan,Muhammad Tauseef |
| author2 | Aslam,Farhan Rasool,Bilal Imran,Muhammad Ahmad,Atif Nisar Tariq,Hafiza Bushra Afzal,Muhammad Inam Rehman,Habib-ur Shahbaz,Muhammad Nadeem,Muhammad |
| author2_role | author author author author author author author author author |
| author_browse | Afzal,Muhammad Inam Ahmad,Atif Nisar Aslam,Farhan Imran,Muhammad Nadeem,Muhammad Rasool,Bilal Rehman,Habib-ur Shahbaz,Muhammad Sultan,Muhammad Tauseef Tariq,Hafiza Bushra |
| author_facet | Sultan,Muhammad Tauseef Aslam,Farhan Rasool,Bilal Imran,Muhammad Ahmad,Atif Nisar Tariq,Hafiza Bushra Afzal,Muhammad Inam Rehman,Habib-ur Shahbaz,Muhammad Nadeem,Muhammad |
| author_role | author |
| collection | Food Science and Technology (Campinas) |
| description | Abstract In this era, various traditional medicinal herbs were researched for their toxicological and safety aspects. The present study focused on using Nigella sativa fixed (NSFO) and essential oil (NSEO) to mitigate the adverse consequences of oxidative stress. For the purpose, oxidative stress was induced in Sprague Dawley rats using potassium bromate injection. The effect of NSFO and NSEO on indices of serum chemistry and hematology were studied. The results indicated that potassium bromate imparted drastic changes in serum chemistry and hematology e.g. it increased the blood cholesterol and blood glucose along with decreasing the insulin secretion. Oxidative stress also influenced the hematological attributes negatively but experimental diets were slightly successful in normalizing the values. The experimental diets especially essential oil that contains significant quantities of thymoquinone modulated the adverse consequences of oxidative stress with special reference to hematology and serological attributes. In the nutshell, NSFO and NSEO hold potential to mitigate the oxidative stress, and improved various serological and hematological attributes. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_44b9b1ee9c8bd0e8a2ed859a4e0f0446 |
| institution | SBCTA |
| instname_str | Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
| language | eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:scielo:S0101-20612021000200404 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
| publisherStr | Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
| reponame_str | Food Science and Technology (Campinas) |
| spelling | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology Sultan,Muhammad Tauseef Aslam,Farhan Rasool,Bilal Imran,Muhammad Ahmad,Atif Nisar Tariq,Hafiza Bushra Afzal,Muhammad Inam Rehman,Habib-ur Shahbaz,Muhammad Nadeem,Muhammad functional foods oxidative stress N. sativa antioxidant thymoquinone Abstract In this era, various traditional medicinal herbs were researched for their toxicological and safety aspects. The present study focused on using Nigella sativa fixed (NSFO) and essential oil (NSEO) to mitigate the adverse consequences of oxidative stress. For the purpose, oxidative stress was induced in Sprague Dawley rats using potassium bromate injection. The effect of NSFO and NSEO on indices of serum chemistry and hematology were studied. The results indicated that potassium bromate imparted drastic changes in serum chemistry and hematology e.g. it increased the blood cholesterol and blood glucose along with decreasing the insulin secretion. Oxidative stress also influenced the hematological attributes negatively but experimental diets were slightly successful in normalizing the values. The experimental diets especially essential oil that contains significant quantities of thymoquinone modulated the adverse consequences of oxidative stress with special reference to hematology and serological attributes. In the nutshell, NSFO and NSEO hold potential to mitigate the oxidative stress, and improved various serological and hematological attributes. Sociedade Brasileira de Ciência e Tecnologia de Alimentos http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200404 |
| spellingShingle | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology Sultan,Muhammad Tauseef functional foods oxidative stress N. sativa antioxidant thymoquinone |
| status_str | publishedVersion |
| title | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| title_full | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| title_fullStr | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| title_full_unstemmed | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| title_short | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| title_sort | Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology |
| topic | functional foods oxidative stress N. sativa antioxidant thymoquinone |
| topic_facet | functional foods oxidative stress N. sativa antioxidant thymoquinone |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200404 |