Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the populati...
| Authors: | ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2005 |
| Country: | Brasil |
| Institution: | UFPA |
| Repository: | Repositório Institucional da UFPA |
| Language: | English |
| OAI Identifier: | oai:repositorio.ufpa.br:2011/3595 |
| Online Access: | http://repositorio.ufpa.br/jspui/handle/2011/3595 |
| Access Level: | Open access |
| Keyword: | Polimorfismo genético Receptor CCR2 Receptor CCR5 Receptor SDF1 HIV-1 Síndrome de Imunodeficiência Adquirida Frequência do gene Belém - PA Pará - Estado Amazônia brasileira |
| _version_ | 1878752784670523392 |
|---|---|
| author | CARVALHAES, Fernanda Andreza de Pinho Lott |
| author2 | CARDOSO, Greice de Lemos VALLINOTO, Antonio Carlos Rosário MACHADO, Luiz Fernando Almeida ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo GUERREIRO, João Farias |
| author2_role | author author author author author author |
| author_browse | CARDOSO, Greice de Lemos CARVALHAES, Fernanda Andreza de Pinho Lott GUERREIRO, João Farias ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo MACHADO, Luiz Fernando Almeida VALLINOTO, Antonio Carlos Rosário |
| author_facet | CARVALHAES, Fernanda Andreza de Pinho Lott CARDOSO, Greice de Lemos VALLINOTO, Antonio Carlos Rosário MACHADO, Luiz Fernando Almeida ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo GUERREIRO, João Farias |
| author_role | author |
| bitstream_url_str_mv | https://repositorio.ufpa.br/oai/bitstream/2011/3595/1/Artigo_FrequenciesCCR5-D32.pdf https://repositorio.ufpa.br/oai/bitstream/2011/3595/2/license_url https://repositorio.ufpa.br/oai/bitstream/2011/3595/3/license_text https://repositorio.ufpa.br/oai/bitstream/2011/3595/4/license_rdf https://repositorio.ufpa.br/oai/bitstream/2011/3595/5/license.txt https://repositorio.ufpa.br/oai/bitstream/2011/3595/6/Artigo_FrequenciesCCR5-D32.pdf.txt |
| collection | Repositório Institucional da UFPA |
| description | The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_2d8b00a1737b7d2fda3554d433387d74 |
| institution | UFPA |
| instname_str | Universidade Federal do Pará (UFPA) |
| language | eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:repositorio.ufpa.br:2011/3595 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| reponame_str | Repositório Institucional da UFPA |
| spelling | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia CARVALHAES, Fernanda Andreza de Pinho Lott CARDOSO, Greice de Lemos VALLINOTO, Antonio Carlos Rosário MACHADO, Luiz Fernando Almeida ISHAK, Marluísa de Oliveira Guimarães ISHAK, Ricardo GUERREIRO, João Farias Polimorfismo genético Receptor CCR2 Receptor CCR5 Receptor SDF1 HIV-1 Síndrome de Imunodeficiência Adquirida Frequência do gene Belém - PA Pará - Estado Amazônia brasileira The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error. CARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <http://www.scielo.br/pdf/gmb/v28n4/a04v28n4.pdf>. Acesso em: 25 mar. 2013. <http://dx.doi.org/10.1590/S1415-47572005000500004>. 1678-4685 1415-4757 http://repositorio.ufpa.br/jspui/handle/2011/3595 |
| spellingShingle | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia CARVALHAES, Fernanda Andreza de Pinho Lott Polimorfismo genético Receptor CCR2 Receptor CCR5 Receptor SDF1 HIV-1 Síndrome de Imunodeficiência Adquirida Frequência do gene Belém - PA Pará - Estado Amazônia brasileira |
| status_str | publishedVersion |
| title | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| title_full | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| title_fullStr | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| title_full_unstemmed | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| title_short | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| title_sort | Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia |
| topic | Polimorfismo genético Receptor CCR2 Receptor CCR5 Receptor SDF1 HIV-1 Síndrome de Imunodeficiência Adquirida Frequência do gene Belém - PA Pará - Estado Amazônia brasileira |
| topic_facet | Polimorfismo genético Receptor CCR2 Receptor CCR5 Receptor SDF1 HIV-1 Síndrome de Imunodeficiência Adquirida Frequência do gene Belém - PA Pará - Estado Amazônia brasileira |
| url | http://repositorio.ufpa.br/jspui/handle/2011/3595 |