Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates
James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, QLD, Australia
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2015 |
| País: | Brasil |
| Institución: | FIOCRUZ |
| Repositorio: | Repositório Institucional da FIOCRUZ (ARCA) |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:arca.fiocruz.br:icict/12814 |
| Acceso en línea: | https://arca.fiocruz.br/handle/icict/12814 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | schistosomiasis protein microarray vaccine human drug-induced resistance 03 Saúde e Bem-Estar |
| _version_ | 1878750560062013440 |
|---|---|
| author | Pearson, Mark S. |
| author2 | Becker, Luke Driguez, Patrick Young, Neil D. Jangola, Soraya Torres Gaze Mendes, Tiago Li, Xiao-Hong Doolan, Denise L. Midzi, Nicholas Mduluza, Takafira Mcmanus, Donald P. Wilson, R. Alan Bethony, Jeffrey Michael Nausch, Norman Mutapi, Francisca Felgner, Philip L. Loukas, Alex |
| author2_role | author author author author author author author author author author author author author author author author |
| author_browse | Becker, Luke Bethony, Jeffrey Michael Doolan, Denise L. Driguez, Patrick Felgner, Philip L. Jangola, Soraya Torres Gaze Li, Xiao-Hong Loukas, Alex Mcmanus, Donald P. Mduluza, Takafira Mendes, Tiago Midzi, Nicholas Mutapi, Francisca Nausch, Norman Pearson, Mark S. Wilson, R. Alan Young, Neil D. |
| author_facet | Pearson, Mark S. Becker, Luke Driguez, Patrick Young, Neil D. Jangola, Soraya Torres Gaze Mendes, Tiago Li, Xiao-Hong Doolan, Denise L. Midzi, Nicholas Mduluza, Takafira Mcmanus, Donald P. Wilson, R. Alan Bethony, Jeffrey Michael Nausch, Norman Mutapi, Francisca Felgner, Philip L. Loukas, Alex |
| author_role | author |
| bitstream_url_str_mv | https://arca.fiocruz.br/bitstreams/609f06f2-3e69-4b60-9f19-b116ee7188a1/download https://arca.fiocruz.br/bitstreams/b3a32914-c9bf-4da2-a54b-81f07dedad33/download https://arca.fiocruz.br/bitstreams/c5be4653-c2f9-494b-9291-e0bb7158c25e/download https://arca.fiocruz.br/bitstreams/be4eec88-a3d8-4ddc-bfd6-f069f6e6fd8b/download |
| collection | Repositório Institucional da FIOCRUZ (ARCA) |
| description | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, QLD, Australia |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_1000b86d2a32bf2685fb8d82f2c7d8cd |
| identifier_str_mv | 10.3389/fimmu.2015.00213 |
| institution | FIOCRUZ |
| instname_str | Fundação Oswaldo Cruz (FIOCRUZ) |
| language | eng |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:arca.fiocruz.br:icict/12814 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Frontiers Media S.A. |
| publisherStr | Frontiers Media S.A. |
| reponame_str | Repositório Institucional da FIOCRUZ (ARCA) |
| spelling | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates Pearson, Mark S. Becker, Luke Driguez, Patrick Young, Neil D. Jangola, Soraya Torres Gaze Mendes, Tiago Li, Xiao-Hong Doolan, Denise L. Midzi, Nicholas Mduluza, Takafira Mcmanus, Donald P. Wilson, R. Alan Bethony, Jeffrey Michael Nausch, Norman Mutapi, Francisca Felgner, Philip L. Loukas, Alex schistosomiasis protein microarray vaccine human drug-induced resistance 03 Saúde e Bem-Estar James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, QLD, Australia QIMR Berghofer Medical Research Institute. Brisbane, QLD, Australia University of Melbourne. Melbourne, VIC, Australia Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil Universidade Federal d Minas Gerais. Belo Horizonte, MG, Brasil National Institute of Parasitic Diseases. Shanghai, China National Institutes of Health Research. Harare, Zimbabwe University of Zimbabwe. Department of Biochemistry. Harare, Zimbabwe University of York. Department of Biology. York, UK George Washington University. Department of Microbiology, Immunology and Tropical Medicine. Washington, DC, USA University of Edinburgh. Edinburgh, UK University of California Irvine, Irvine, CA, USA Schistosoma haematobium affects more than 100 million people throughout Africa and is the causative agent of urogenital schistosomiasis. The parasite is strongly associated with urothelial cancer in infected individuals and as such is designated a group I carcinogen by the International Agency for Research on Cancer. Using a protein microarray containing schistosome proteins, we sought to identify antigens that were the targets of protective IgG1 immune responses in S. haematobium exposed individuals that acquire drug-induced resistance (DIR) to schistosomiasis after praziquantel treatment. Numerous antigens with known vaccine potential were identified, including calpain (Smp80), tetraspanins, glutathione-S -transferases, and glucose transporters (SGTP1), as well as previously uncharacterized proteins. Reactive IgG1 responses were not elevated in exposed individuals who did not acquire DIR. To complement our human subjects study, we screened for antigen targets of rhesus macaques rendered resistant to S. japonicum by experimental infection followed by self-cure, and discovered a number of new and known vaccine targets, including major targets recognized by our human subjects. This study has further validated the immunomics-based approach to schistosomiasis vaccine antigen discovery and identified numerous novel potential vaccine antigens Frontiers Media S.A. PEARSON, Mark S. Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates. Front Immunol. ,vol. 6, p. 213, 2015. 1664-3224 https://arca.fiocruz.br/handle/icict/12814 10.3389/fimmu.2015.00213 |
| spellingShingle | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates Pearson, Mark S. schistosomiasis protein microarray vaccine human drug-induced resistance 03 Saúde e Bem-Estar |
| status_str | publishedVersion |
| title | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| title_full | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| title_fullStr | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| title_full_unstemmed | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| title_short | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| title_sort | Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates |
| topic | schistosomiasis protein microarray vaccine human drug-induced resistance 03 Saúde e Bem-Estar |
| topic_facet | schistosomiasis protein microarray vaccine human drug-induced resistance 03 Saúde e Bem-Estar |
| url | https://arca.fiocruz.br/handle/icict/12814 |