Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas
This paper proposes a methodology for spectrophotometric determination of hexamethylenetetramine (HMT) by using chromotropic acid in a phosphoric acid media employing a domestic microwave oven as a source of heating. The reddish-purple soluble product is quantitatively formed after 30 s of irradiati...
| Autores: | ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2009 |
| País: | Brasil |
| Institución: | UNESP |
| Repositorio: | Repositório Institucional da UNESP |
| Lenguaje: | Portugués |
| OAI Identifier: | oai:repositorio.unesp.br:11449/231905 |
| Acceso en línea: | http://hdl.handle.net/11449/231905 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Chromotropic acid Hexamethylenetetramine Microwave oven |
| _version_ | 1878750085652676608 |
|---|---|
| author | Fagnani, Enelton |
| author2 | Pezza, Leonardo [UNESP] Pezza, Helena Redigolo [UNESP] |
| author2_role | author author |
| author_browse | Fagnani, Enelton Pezza, Helena Redigolo [UNESP] Pezza, Leonardo [UNESP] |
| author_facet | Fagnani, Enelton Pezza, Leonardo [UNESP] Pezza, Helena Redigolo [UNESP] |
| author_role | author |
| collection | Repositório Institucional da UNESP |
| description | This paper proposes a methodology for spectrophotometric determination of hexamethylenetetramine (HMT) by using chromotropic acid in a phosphoric acid media employing a domestic microwave oven as a source of heating. The reddish-purple soluble product is quantitatively formed after 30 s of irradiation and obeys the Beeŕs law in the range between 0.1-1.2 mg L-1 HMT (r = 0.99925). The method was applied successfully in commercial pharmaceutical preparations containing dyes in their composition. The results showed that the method proposed is feasible for simplicity, speed, low cost, precision and accuracy when compared with United States Pharmacopeia official method. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | BR_0a3e8dff4d7e34a2dad094e00459c4fa |
| institution | UNESP |
| instname_str | Universidade Estadual Paulista (UNESP) |
| language | por |
| network_acronym_str | BR |
| network_name_str | Brasil |
| oai_identifier_str | oai:repositorio.unesp.br:11449/231905 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| reponame_str | Repositório Institucional da UNESP |
| spelling | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas Spectrophotometric determination of hexamethylenetetramine (HMT) in pharmaceutical preparations using chromotropic acid and microwave oven Fagnani, Enelton Pezza, Leonardo [UNESP] Pezza, Helena Redigolo [UNESP] Chromotropic acid Hexamethylenetetramine Microwave oven This paper proposes a methodology for spectrophotometric determination of hexamethylenetetramine (HMT) by using chromotropic acid in a phosphoric acid media employing a domestic microwave oven as a source of heating. The reddish-purple soluble product is quantitatively formed after 30 s of irradiation and obeys the Beeŕs law in the range between 0.1-1.2 mg L-1 HMT (r = 0.99925). The method was applied successfully in commercial pharmaceutical preparations containing dyes in their composition. The results showed that the method proposed is feasible for simplicity, speed, low cost, precision and accuracy when compared with United States Pharmacopeia official method. Faculdade de Engenharia Civil, Arquitetura e Urbanismo Universidade Estadual de Campinas, CP 6021, 13083-852 Campinas - SP Instituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara - SP Quimica Nova, v. 32, n. 9, p. 2458-2463, 2009. 0100-4042 1678-7064 http://hdl.handle.net/11449/231905 2-s2.0-75649090824 |
| spellingShingle | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas Fagnani, Enelton Chromotropic acid Hexamethylenetetramine Microwave oven |
| status_str | publishedVersion |
| title | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| title_full | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| title_fullStr | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| title_full_unstemmed | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| title_short | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| title_sort | Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas |
| topic | Chromotropic acid Hexamethylenetetramine Microwave oven |
| topic_facet | Chromotropic acid Hexamethylenetetramine Microwave oven |
| url | http://hdl.handle.net/11449/231905 |