Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation
Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory re...
| Autores: | ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2015 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/115080 |
| Acceso en línea: | http://hdl.handle.net/11336/115080 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | ERK INHIBITORY AVOIDANCE MAPK MEMORY RECONSOLIDATION MICE PD098059 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| _version_ | 1878403991256170496 |
|---|---|
| author | Krawczyk, Maria del Carmen |
| author2 | Blake, Mariano Guillermo Baratti, Carlos Maria Romano, Arturo Gabriel Boccia, Mariano Martín Feld, Mariana |
| author2_role | author author author author author |
| author_browse | Baratti, Carlos Maria Blake, Mariano Guillermo Boccia, Mariano Martín Feld, Mariana Krawczyk, Maria del Carmen Romano, Arturo Gabriel |
| author_facet | Krawczyk, Maria del Carmen Blake, Mariano Guillermo Baratti, Carlos Maria Romano, Arturo Gabriel Boccia, Mariano Martín Feld, Mariana |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | AR_e6c8c45230fb9cf89206e9e3b7bbf2e8 |
| identifier_str_mv | Krawczyk, Maria del Carmen; Blake, Mariano Guillermo; Baratti, Carlos Maria; Romano, Arturo Gabriel; Boccia, Mariano Martín; et al.; Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation; Pergamon-Elsevier Science Ltd; Neuroscience; 294; 5-2015; 227-237 0306-4522 CONICET Digital CONICET |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/115080 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Pergamon-Elsevier Science Ltd |
| publisherStr | Pergamon-Elsevier Science Ltd |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation Krawczyk, Maria del Carmen Blake, Mariano Guillermo Baratti, Carlos Maria Romano, Arturo Gabriel Boccia, Mariano Martín Feld, Mariana ERK INHIBITORY AVOIDANCE MAPK MEMORY RECONSOLIDATION MICE PD098059 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. Fil: Krawczyk, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina Fil: Blake, Mariano Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina Fil: Baratti, Carlos Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina Fil: Romano, Arturo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Boccia, Mariano Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina Fil: Feld, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Pergamon-Elsevier Science Ltd http://hdl.handle.net/11336/115080 Krawczyk, Maria del Carmen; Blake, Mariano Guillermo; Baratti, Carlos Maria; Romano, Arturo Gabriel; Boccia, Mariano Martín; et al.; Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation; Pergamon-Elsevier Science Ltd; Neuroscience; 294; 5-2015; 227-237 0306-4522 CONICET Digital CONICET |
| spellingShingle | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation Krawczyk, Maria del Carmen ERK INHIBITORY AVOIDANCE MAPK MEMORY RECONSOLIDATION MICE PD098059 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| status_str | publishedVersion |
| title | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| title_full | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| title_fullStr | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| title_full_unstemmed | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| title_short | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| title_sort | Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
| topic | ERK INHIBITORY AVOIDANCE MAPK MEMORY RECONSOLIDATION MICE PD098059 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| topic_facet | ERK INHIBITORY AVOIDANCE MAPK MEMORY RECONSOLIDATION MICE PD098059 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| url | http://hdl.handle.net/11336/115080 |