Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks...
| Autores: | ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2007 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/61638 |
| Acceso en línea: | http://hdl.handle.net/11336/61638 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | 6-Hydroxydopamine Electroconvulsive Shock Glial Cell-Line Derived Neurotrophic Factor Neuroprotection Parkinson Substantia Nigra https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| _version_ | 1878403762762022912 |
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| author | Anastasia Gonzalez, Agustin |
| author2 | de Erausquin, Gabriel Alejandro Wojnacki Fonseca, José Ignacio Masco, Daniel Hugo |
| author2_role | author author author |
| author_browse | Anastasia Gonzalez, Agustin Masco, Daniel Hugo Wojnacki Fonseca, José Ignacio de Erausquin, Gabriel Alejandro |
| author_facet | Anastasia Gonzalez, Agustin de Erausquin, Gabriel Alejandro Wojnacki Fonseca, José Ignacio Masco, Daniel Hugo |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | AR_bbbe8b0d4e0fc2c6528cfa95ccc17aae |
| identifier_str_mv | Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo; Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 103; 4; 26-11-2007; 1542-1552 0022-3042 1471-4159 CONICET Digital CONICET |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/61638 |
| publishDate | 2007 |
| publishDateSort | 2007 |
| publisher | Wiley Blackwell Publishing, Inc |
| publisherStr | Wiley Blackwell Publishing, Inc |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease Anastasia Gonzalez, Agustin de Erausquin, Gabriel Alejandro Wojnacki Fonseca, José Ignacio Masco, Daniel Hugo 6-Hydroxydopamine Electroconvulsive Shock Glial Cell-Line Derived Neurotrophic Factor Neuroprotection Parkinson Substantia Nigra https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors. Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina Fil: de Erausquin, Gabriel Alejandro. The George Washington University; Estados Unidos Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina Fil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina Wiley Blackwell Publishing, Inc http://hdl.handle.net/11336/61638 Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo; Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 103; 4; 26-11-2007; 1542-1552 0022-3042 1471-4159 CONICET Digital CONICET |
| spellingShingle | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease Anastasia Gonzalez, Agustin 6-Hydroxydopamine Electroconvulsive Shock Glial Cell-Line Derived Neurotrophic Factor Neuroprotection Parkinson Substantia Nigra https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| status_str | publishedVersion |
| title | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| title_full | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| title_fullStr | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| title_full_unstemmed | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| title_short | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| title_sort | Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease |
| topic | 6-Hydroxydopamine Electroconvulsive Shock Glial Cell-Line Derived Neurotrophic Factor Neuroprotection Parkinson Substantia Nigra https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| topic_facet | 6-Hydroxydopamine Electroconvulsive Shock Glial Cell-Line Derived Neurotrophic Factor Neuroprotection Parkinson Substantia Nigra https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| url | http://hdl.handle.net/11336/61638 |