Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis

The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoi...

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Authors: Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; Perez Leiros, Claudia
Format: Article
Status:Published version
Publication date:2005
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/39392
Online Access:http://hdl.handle.net/11336/39392
Access Level:Open access
Keyword:Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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author Rosignoli, F.
author2 Roca, Valeria Ines
Meiss, R.
Leceta, J.
Gomariz, Roberto Luis
Perez Leiros, Claudia
author2_role author
author
author
author
author
author_browse Gomariz, Roberto Luis
Leceta, J.
Meiss, R.
Perez Leiros, Claudia
Roca, Valeria Ines
Rosignoli, F.
author_facet Rosignoli, F.
Roca, Valeria Ines
Meiss, R.
Leceta, J.
Gomariz, Roberto Luis
Perez Leiros, Claudia
author_role author
collection CONICET Digital (CONICET)
description The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response.
eu_rights_str_mv openAccess
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id AR_7449f4e89aea4cf9d8eea5cfdca6c7d1
identifier_str_mv Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418
0009-9104
1365-2249
CONICET Digital
CONICET
institution Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
language eng
network_acronym_str AR
network_name_str Argentina
oai_identifier_str oai:ri.conicet.gov.ar:11336/39392
publishDate 2005
publishDateSort 2005
publisher Wiley Blackwell Publishing, Inc
publisherStr Wiley Blackwell Publishing, Inc
reponame_str CONICET Digital (CONICET)
spelling Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis Rosignoli, F. Roca, Valeria Ines Meiss, R. Leceta, J. Gomariz, Roberto Luis Perez Leiros, Claudia Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. Fil: Rosignoli, F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Complutense de Madrid; España Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Meiss, R.. Academia Nacional de Medicina de Buenos Aires; Argentina Fil: Leceta, J.. Universidad Complutense de Madrid; España Fil: Gomariz, R.P.. Universidad Complutense de Madrid; España Fil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Wiley Blackwell Publishing, Inc http://hdl.handle.net/11336/39392 Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418 0009-9104 1365-2249 CONICET Digital CONICET
spellingShingle Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
Rosignoli, F.
Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
status_str publishedVersion
title Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_fullStr Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_full_unstemmed Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_short Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
title_sort Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
topic Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic_facet Autoimmune Response
Nitric Oxide Signalling
Nod Mice
Sialadenitis
SjÖGren'S Syndrome
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
url http://hdl.handle.net/11336/39392

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