Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease

Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased sera levels of soluble P-selectin are associated with the severity of the ca...

Descripción completa

Autores: Pengue, Claudia; Cesar, Gonzalo Leandro; Alvarez, María Gabriela; Bertocchi, Graciela Luciana; Lococo, Bruno Edgardo; Viotti, Rodolfo Jorge; Natale, Maria Ailen; Castro Eiro, Melisa Daiana; Cambiazzo, Silvia S.; Perroni, Nancy; Nuñez, Myriam; Albareda, María Cecilia; Laucella, Susana Adriana
Tipo de documento: Artículo
Estado:Published version
Fecha de publicación:2019
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Lenguaje:Inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/130126
Acceso en línea:http://hdl.handle.net/11336/130126
Nivel de acceso:Acceso abierto
Palabra clave:PLATELET
CHAGAS
TRYPANOSOMA CRUZI
PROCOLLAGEN
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
Sumario:Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased sera levels of soluble P-selectin are associated with the severity of the cardiomyopathy distinctive of chronic Chagas disease. In this study, we explored the expression of biomarkers of platelet and endothelial activation, tissue remodeling, and mediators of the coagulation cascade in patients at different clinical stages of chronic Chagas heart disease. The frequencies of activated platelets, measured by the expression of CD41a and CD62P were decreased in patients with chronic Chagas disease compared with those in uninfected subjects, with an inverse association with disease severity. Platelet activation in response to adenosine diphosphate was also decreased in T. cruziinfected subjects. A major proportion of T. cruzi infected subjects showed increased serum levels of fibrinogen. Patients with severe cardiac dysfunction showed increased levels of endothelin-1 and normal values of procollagen I. In conclusion, chronic infection with T. cruzi induced hemostatic alterations, even in those patients who do not yet present cardiac symptoms.

Ejemplares similares