HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator...

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Authors: Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; Yuan, Wei; Lundberg, Derek S.; Weigel, Detlef; Manavella, Pablo Andrés
Format: Article
Status:Published version
Publication date:2021
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/145316
Online Access:http://hdl.handle.net/11336/145316
Access Level:Open access
Keyword:GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Summary:HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.

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