Phase transitions in tumor growth VI: Epithelial–Mesenchymal transition

Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transiti...

Full description

Authors: Guerra, A.; Rodriguez, D. J.; Montero, S.; Betancourt Mar, J. A.; Martín Pardo, Reinaldo Román; Silva Lamar, Eduardo; Bizzarri, María Julia; Cocho, G.; Mansilla, R.; Nieto Villar, José Manuel
Format: Article
Status:Published version
Publication date:2018
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/120752
Online Access:http://hdl.handle.net/11336/120752
Access Level:Open access
Keyword:BIOLOGICAL PHASE TRANSITION
ENTROPY PRODUCTION RATE
EPITHELIAL–MESENCHYMAL TRANSITION
PHENOTYPIC TRANSITIONS IN CANCER CELL EVOLUTION
TUMOR-MICROENVIRONMENT CROSS-TALK
https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
Summary:Herewith we discuss a network model of the epithelial–mesenchymal transition (EMT) based on our previous proposed framework. The EMT appears as a “first order” phase transition process, analogous to the transitions observed in the chemical–physical field. Chiefly, EMT should be considered a transition characterized by a supercritical Andronov–Hopf bifurcation, with the emergence of limit cycle and, consequently, a cascade of saddle-foci Shilnikov's bifurcations. We eventually show that the entropy production rate is an EMT-dependent function and, as such, its formalism reminds the van der Waals equation.

Similar Items