Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling
Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of partic...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2017 |
| Country: | Argentina |
| Institution: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repository: | CONICET Digital (CONICET) |
| Language: | English |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/34433 |
| Online Access: | http://hdl.handle.net/11336/34433 |
| Access Level: | Open access |
| Keyword: | DRUG DELIVERY MATHEMATICAL MODELING MICROPARTICLES POLY(LACTIC-CO-GLYCOLIC ACID) PROGESTERONE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| _version_ | 1878403045158551552 |
|---|---|
| author | Busatto, Carlos Alberto |
| author2 | Pesoa, Juan Ignacio Helbling, Ignacio Marcelo Luna, Julio Alberto Estenoz, Diana Alejandra |
| author2_role | author author author author |
| author_browse | Busatto, Carlos Alberto Estenoz, Diana Alejandra Helbling, Ignacio Marcelo Luna, Julio Alberto Pesoa, Juan Ignacio |
| author_facet | Busatto, Carlos Alberto Pesoa, Juan Ignacio Helbling, Ignacio Marcelo Luna, Julio Alberto Estenoz, Diana Alejandra |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile. This behavior is related to the fact that complete drug release was achieved in a few days for smaller microparticles, during which polymer degradation effects are still negligible. A mathematical model was developed that predicts the progesterone release profiles from different-sized PLGA microspheres. The model takes into account both the dissolution and diffusion of the drug in the polymeric matrix as well as the autocatalytic effect of polymer degradation. The model was adjusted and validated with novel experimental data. Simulation results are in very good agreement with experimental results. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | AR_32bb40b8564b2cad5e441d848e3a6793 |
| identifier_str_mv | Busatto, Carlos Alberto; Pesoa, Juan Ignacio; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Estenoz, Diana Alejandra; Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling; Elsevier Science; International Journal Of Pharmaceutics; 536; 1; 12-2017; 360-369 0378-5173 CONICET Digital CONICET |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/34433 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Elsevier Science |
| publisherStr | Elsevier Science |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling Busatto, Carlos Alberto Pesoa, Juan Ignacio Helbling, Ignacio Marcelo Luna, Julio Alberto Estenoz, Diana Alejandra DRUG DELIVERY MATHEMATICAL MODELING MICROPARTICLES POLY(LACTIC-CO-GLYCOLIC ACID) PROGESTERONE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 Poly(lactic-co-glycolic acid) (PLGA) microparticles containing progesterone were prepared by the solvent extraction/evaporation and microfluidic techniques. Microparticles were characterized by their size distribution, encapsulation efficiency, morphology and thermal properties. The effect of particle size, polydispersity and polymer degradation on the in vitro release of the hormone was studied. A triphasic release profile was observed for larger microparticles, while smaller microspheres showed a biphasic release profile. This behavior is related to the fact that complete drug release was achieved in a few days for smaller microparticles, during which polymer degradation effects are still negligible. A mathematical model was developed that predicts the progesterone release profiles from different-sized PLGA microspheres. The model takes into account both the dissolution and diffusion of the drug in the polymeric matrix as well as the autocatalytic effect of polymer degradation. The model was adjusted and validated with novel experimental data. Simulation results are in very good agreement with experimental results. Fil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Pesoa, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Elsevier Science http://hdl.handle.net/11336/34433 Busatto, Carlos Alberto; Pesoa, Juan Ignacio; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Estenoz, Diana Alejandra; Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling; Elsevier Science; International Journal Of Pharmaceutics; 536; 1; 12-2017; 360-369 0378-5173 CONICET Digital CONICET |
| spellingShingle | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling Busatto, Carlos Alberto DRUG DELIVERY MATHEMATICAL MODELING MICROPARTICLES POLY(LACTIC-CO-GLYCOLIC ACID) PROGESTERONE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| status_str | publishedVersion |
| title | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| title_full | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| title_fullStr | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| title_full_unstemmed | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| title_short | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| title_sort | Effect of particle size, polydispersity and polymer degradation on progesterone release from PLGA microparticles: Experimental and mathematical modeling |
| topic | DRUG DELIVERY MATHEMATICAL MODELING MICROPARTICLES POLY(LACTIC-CO-GLYCOLIC ACID) PROGESTERONE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| topic_facet | DRUG DELIVERY MATHEMATICAL MODELING MICROPARTICLES POLY(LACTIC-CO-GLYCOLIC ACID) PROGESTERONE https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| url | http://hdl.handle.net/11336/34433 |