Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our s...
| Autores: | ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Estado: | Published version |
| Data de publicação: | 2010 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositório: | CONICET Digital (CONICET) |
| Idioma: | Inglês |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/14719 |
| Acesso em linha: | http://hdl.handle.net/11336/14719 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| _version_ | 1878402843455520768 |
|---|---|
| author | Mac Keon, Soledad |
| author2 | Gazzaniga, Silvina Noemí Mallerman, Julieta Bravo, Alicia Inés Mordoh, Jose Wainstok, Rosa |
| author2_role | author author author author author |
| author_browse | Bravo, Alicia Inés Gazzaniga, Silvina Noemí Mac Keon, Soledad Mallerman, Julieta Mordoh, Jose Wainstok, Rosa |
| author_facet | Mac Keon, Soledad Gazzaniga, Silvina Noemí Mallerman, Julieta Bravo, Alicia Inés Mordoh, Jose Wainstok, Rosa |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our system and to find out if there is an immunological response taking place at the vaccination site. The formation of a pseudocapsule, peripheral node addresin expression in small venules, and the recruitment of a wide variety of cellular populations, including macrophages, polymorphonuclear lymphocytes, and CD8+ and CD4+ T lymphocytes found in association with DC, evidenced the formation of tertiary lymphoid tissue in the vaccination site in our experimental system. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | AR_0d26bb9ffaa0d2f6317ebfb0ea4e0df6 |
| identifier_str_mv | Mac Keon, Soledad; Gazzaniga, Silvina Noemí; Mallerman, Julieta; Bravo, Alicia Inés; Mordoh, Jose; et al.; Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue; Elsevier; Vaccine; 28; 51; 11-2010; 8162-8168 1873-2518 |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/14719 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue Mac Keon, Soledad Gazzaniga, Silvina Noemí Mallerman, Julieta Bravo, Alicia Inés Mordoh, Jose Wainstok, Rosa Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our system and to find out if there is an immunological response taking place at the vaccination site. The formation of a pseudocapsule, peripheral node addresin expression in small venules, and the recruitment of a wide variety of cellular populations, including macrophages, polymorphonuclear lymphocytes, and CD8+ and CD4+ T lymphocytes found in association with DC, evidenced the formation of tertiary lymphoid tissue in the vaccination site in our experimental system. Fil: Mac Keon, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Gazzaniga, Silvina Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Mallerman, Julieta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Bravo, Alicia Inés. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; Argentina Fil: Mordoh, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina Fil: Wainstok, Rosa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina Elsevier http://hdl.handle.net/11336/14719 Mac Keon, Soledad; Gazzaniga, Silvina Noemí; Mallerman, Julieta; Bravo, Alicia Inés; Mordoh, Jose; et al.; Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue; Elsevier; Vaccine; 28; 51; 11-2010; 8162-8168 1873-2518 |
| spellingShingle | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue Mac Keon, Soledad Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| status_str | publishedVersion |
| title | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| title_full | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| title_fullStr | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| title_full_unstemmed | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| title_short | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| title_sort | Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue |
| topic | Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| topic_facet | Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| url | http://hdl.handle.net/11336/14719 |