Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function...
| Autores: | ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Data de publicação: | 2018 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositório: | Docta Complutense |
| Idioma: | Inglês |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/97122 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/97122 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | 577.27 T cell activation microRNAs (miRNAs) Immunoregulatory molecules miRNA signature CD4 CD8 T lymphocyte Biología celular (Biología) Biología molecular (Biología) Bioquímica (Biología) Inmunología 2403 Bioquímica 2407 Biología Celular 2412 Inmunología 2415 Biología Molecular |
| Resumo: | MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. |
|---|