Autophagy in Tissue Repair and Regeneration
Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations...
| Autores: | ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/219657 |
| Acceso en línea: | https://hdl.handle.net/2445/219657 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Autofàgia Cèl·lules mare Regeneració (Biologia) Autophagy Stem cells Regeneration (Biology) |
| _version_ | 1878741135092875264 |
|---|---|
| author | Moreno-Blas, Daniel |
| author2 | Adell i Creixell, Teresa González Estévez, Cristina |
| author2_role | author author |
| author_browse | Adell i Creixell, Teresa González Estévez, Cristina Moreno-Blas, Daniel |
| author_facet | Moreno-Blas, Daniel Adell i Creixell, Teresa González Estévez, Cristina |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations and human diseases, including the loss of regenerative capacity. Tissue regeneration is a highly complex process that relies on the coordinated interplay of several cellular processes, such as injury sensing, defense responses, cell proliferation, differentiation, migration, and cellular senescence. These processes act synergistically to repair or replace damaged tissues and restore their morphology and function. In this review, we examine the evidence supporting the involvement of the autophagy pathway in the different cellular mechanisms comprising the processes of regeneration and repair across different regenerative contexts. Additionally, we explore how modulating autophagy can enhance or accelerate regeneration and repair, highlighting autophagy as a promising therapeutic target in regenerative medicine for the development of autophagy-based treatments for human diseases. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_dfbd0f96bcafc8ee7b1aa16d5dfd9cf3 |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/219657 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Autophagy in Tissue Repair and Regeneration Moreno-Blas, Daniel Adell i Creixell, Teresa González Estévez, Cristina Autofàgia Cèl·lules mare Regeneració (Biologia) Autophagy Stem cells Regeneration (Biology) Autophagy is a cellular recycling system that, through the sequestration and degradation of intracellular components regulates multiple cellular functions to maintain cellular homeostasis and survival. Dysregulation of autophagy is closely associated with the development of physiological alterations and human diseases, including the loss of regenerative capacity. Tissue regeneration is a highly complex process that relies on the coordinated interplay of several cellular processes, such as injury sensing, defense responses, cell proliferation, differentiation, migration, and cellular senescence. These processes act synergistically to repair or replace damaged tissues and restore their morphology and function. In this review, we examine the evidence supporting the involvement of the autophagy pathway in the different cellular mechanisms comprising the processes of regeneration and repair across different regenerative contexts. Additionally, we explore how modulating autophagy can enhance or accelerate regeneration and repair, highlighting autophagy as a promising therapeutic target in regenerative medicine for the development of autophagy-based treatments for human diseases. MDPI https://hdl.handle.net/2445/219657 |
| spellingShingle | Autophagy in Tissue Repair and Regeneration Moreno-Blas, Daniel Autofàgia Cèl·lules mare Regeneració (Biologia) Autophagy Stem cells Regeneration (Biology) |
| status_str | publishedVersion |
| title | Autophagy in Tissue Repair and Regeneration |
| title_full | Autophagy in Tissue Repair and Regeneration |
| title_fullStr | Autophagy in Tissue Repair and Regeneration |
| title_full_unstemmed | Autophagy in Tissue Repair and Regeneration |
| title_short | Autophagy in Tissue Repair and Regeneration |
| title_sort | Autophagy in Tissue Repair and Regeneration |
| topic | Autofàgia Cèl·lules mare Regeneració (Biologia) Autophagy Stem cells Regeneration (Biology) |
| topic_facet | Autofàgia Cèl·lules mare Regeneració (Biologia) Autophagy Stem cells Regeneration (Biology) |
| url | https://hdl.handle.net/2445/219657 |