Square-planar copper(II) complexes from a zwitterionic schiff-base N<sub>2</sub>/N<sub>2/2</sub>-donor ligand: DNA interaction and cytotoxicity
A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and...
| Authors: | ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Universidad de Zaragoza |
| Repository: | Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| OAI Identifier: | oai:zaguan.unizar.es:136350 |
| Online Access: | http://zaguan.unizar.es/record/136350 |
| Access Level: | Open access |
| Summary: | A new tetradentate ligand, namely 3,3′-((1E,1′E)-(ethane-1,2-diylbis(azaneylylidene))bis(methaneylylidene))bis(pyridin-2-amine) (en2ampy) was prepared and two copper(II) complexes, viz. [Cu(en2ampy)]Cl2 (1) and [Cu(en2ampy)](NO3)2 (2), were obtained through its reaction with copper(II) chloride and copper(II) nitrate, respectively. The single-crystal X-ray structure of the compounds showed that the metal centre was coordinated in a square-planar fashion by a doubly deprotonated en2ampy acting as a tetradentate mathematical equation /mathematical equation -donor ligand. DNA-binding studies revealed that 1 and 2 were electrostatically binding to DNA, probably in the grooves and cytotoxicity assays showed that the complexes were clearly more efficient than cisplatin against ovarian carcinoma (A2780) cells and the cisplatin-resistant (A2780Cis) ones. |
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