Molecular characterisation of triple negative essential thrombocythaemia patients by platelet analysis and targeted sequencing.

Essential thrombocythaemia (ET) is a myeloproliferative neoplasm(MPN) characterised by megakaryocyte hyperplasia and thrombo-cytosis. From the genetic perspective, ET patients harbourmutations inJAK2(50–60%),CALR(15–30%) andMPL(1–5%) genes.

Autores: Angona Figueras, Anna; Fernández Rodríguez, M. Concepción; Álvarez Larrán, Alberto; Camacho Díaz, Laura; Longarón Rozalen, Raquel; Torres, Erica; Pairet García, Silvia; Besses Raebel, Carles; Bellosillo Paricio, Beatriz
Tipo de documento: Artigo
Estado:Published version
Data de publicação:2016
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/27900
Acesso em linha:http://hdl.handle.net/10230/27900
http://dx.doi.org/10.1038/bcj.2016.75
Nível de acesso:Acesso aberto
Palavra-chave:Trombocitèmia
Plaquetes sanguínies -- Trastorns
Resumo:Essential thrombocythaemia (ET) is a myeloproliferative neoplasm(MPN) characterised by megakaryocyte hyperplasia and thrombo-cytosis. From the genetic perspective, ET patients harbourmutations inJAK2(50–60%),CALR(15–30%) andMPL(1–5%) genes.

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