The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
COVID-19; Mechanical ventilation; Ventilatory ratio
| Autores: | ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7382 |
| Acceso en línea: | https://hdl.handle.net/11351/7382 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Respiració artificial Prognosi COVID-19 (Malaltia) - Espanya DISEASES::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration, Artificial ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico |
| _version_ | 1878737179241349120 |
|---|---|
| author | Torres-Martí, Antoni |
| author2 | Motos, Anna Riera Del Brío, Jordi Fernández‑Barat, Laia Ceccato, Adrián Pérez‑Arnal, Raquel Ferrer Roca, Ricard |
| author2_role | author author author author author author |
| author_browse | Ceccato, Adrián Fernández‑Barat, Laia Ferrer Roca, Ricard Motos, Anna Pérez‑Arnal, Raquel Riera Del Brío, Jordi Torres-Martí, Antoni |
| author_facet | Torres-Martí, Antoni Motos, Anna Riera Del Brío, Jordi Fernández‑Barat, Laia Ceccato, Adrián Pérez‑Arnal, Raquel Ferrer Roca, Ricard |
| author_role | author |
| collection | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| description | COVID-19; Mechanical ventilation; Ventilatory ratio |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_9bf1ae4eb2eaf2cdfd6f7b2c3f3a5a13 |
| institution | Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str | Departament de Salut de la Generalitat de Catalunya (DS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:scientiasalut.gencat.cat:11351/7382 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | BMC |
| publisherStr | BMC |
| reponame_str | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| spelling | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients Torres-Martí, Antoni Motos, Anna Riera Del Brío, Jordi Fernández‑Barat, Laia Ceccato, Adrián Pérez‑Arnal, Raquel Ferrer Roca, Ricard Respiració artificial Prognosi COVID-19 (Malaltia) - Espanya DISEASES::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration, Artificial ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico COVID-19; Mechanical ventilation; Ventilatory ratio COVID-19; Respiració assistida; Relació ventilatòria COVID-19; Ventilación mecánica; Relación ventilatoria Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0–171.2] to 180.0 [135.4–227.9] mmHg and the ventilatory ratio from 1.73 [1.33–2.25] to 1.96 [1.61–2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01–1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01–1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93–1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation. Financial support was provided by the Instituto de Salud Carlos III de Madrid (COV20/00110, ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa", and by the Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES). DdGC has received financial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by European Social Fund (ESF)/”Investing in your future”. BMC https://hdl.handle.net/11351/7382 |
| spellingShingle | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients Torres-Martí, Antoni Respiració artificial Prognosi COVID-19 (Malaltia) - Espanya DISEASES::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration, Artificial ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico |
| status_str | publishedVersion |
| title | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| title_full | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| title_fullStr | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| title_full_unstemmed | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| title_short | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| title_sort | The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients |
| topic | Respiració artificial Prognosi COVID-19 (Malaltia) - Espanya DISEASES::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration, Artificial ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico |
| topic_facet | Respiració artificial Prognosi COVID-19 (Malaltia) - Espanya DISEASES::Respiratory Tract Diseases::Lung Diseases::Respiratory Distress Syndrome, Adult ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Emergency Treatment::Resuscitation::Therapeutics::Respiration, Artificial ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::síndrome de dificultad respiratoria del adulto TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::tratamiento de urgencia::resucitación::terapéutica::respiración artificial TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico |
| url | https://hdl.handle.net/11351/7382 |