Recent advances in precision nutrition and cardiometabolic diseases
A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in indep...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2025 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/223813 |
| Online Access: | https://hdl.handle.net/2445/223813 |
| Access Level: | Open access |
| Keyword: | Malalties cardiovasculars Nutrició Cardiovascular diseases Nutrition |
| Summary: | A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: <em>a)</em> developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; <em>b)</em> incorporating more diverse populations and a broader range of dietary patterns; and <em>c)</em> conducting more translational research to bridge the gap between precision nutrition studies and clinical applications. |
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