Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial
There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universitat Ramon Llull (URL) |
| Repository: | DAU Arxiu Digital de la Universitat Ramon Llull |
| OAI Identifier: | oai:dau.url.edu:20.500.14342/761 |
| Online Access: | http://hdl.handle.net/20.500.14342/761 https://doi.org/10.3390/nu13020559 |
| Access Level: | Open access |
| Keyword: | Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció 613 616.1 |
| _version_ | 1878736216137924608 |
|---|---|
| author | Hernáez, Álvaro |
| author2 | Lassale, Camille Castro-Barquero, Sara Ros Rahola, Emilio Tresserra-Rimbau, Anna Castañer, Olga Pintó Sala, Xavier Vázquez Ruiz, Zenaida Sorlí, José V. Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Alonso Gómez, Ángel M. Fiol, Miquel Serra Majem, Lluís Sacanella Meseguer, Emilio Razquin, Cristina Corella Piquer, Dolores Guasch-Ferré, Marta Cofán Pujol, Montserrat Estruch Riba, Ramon |
| author2_role | author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alonso Gómez, Ángel M. Castañer, Olga Castro-Barquero, Sara Cofán Pujol, Montserrat Corella Piquer, Dolores Estruch Riba, Ramon Fiol, Miquel Guasch-Ferré, Marta Gómez-Gracia, Enrique Hernáez, Álvaro Lapetra, José Lassale, Camille Pintó Sala, Xavier Razquin, Cristina Ros Rahola, Emilio Sacanella Meseguer, Emilio Salas Salvadó, Jordi Serra Majem, Lluís Sorlí, José V. Tresserra-Rimbau, Anna Vázquez Ruiz, Zenaida |
| author_facet | Hernáez, Álvaro Lassale, Camille Castro-Barquero, Sara Ros Rahola, Emilio Tresserra-Rimbau, Anna Castañer, Olga Pintó Sala, Xavier Vázquez Ruiz, Zenaida Sorlí, José V. Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Alonso Gómez, Ángel M. Fiol, Miquel Serra Majem, Lluís Sacanella Meseguer, Emilio Razquin, Cristina Corella Piquer, Dolores Guasch-Ferré, Marta Cofán Pujol, Montserrat Estruch Riba, Ramon |
| author_role | author |
| collection | DAU Arxiu Digital de la Universitat Ramon Llull |
| description | There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8b1c4cebd856477be9f5b5ed3f25c57f |
| institution | Universitat Ramon Llull (URL) |
| instname_str | Universitat Ramon Llull (URL) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dau.url.edu:20.500.14342/761 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | DAU Arxiu Digital de la Universitat Ramon Llull |
| spelling | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial Hernáez, Álvaro Lassale, Camille Castro-Barquero, Sara Ros Rahola, Emilio Tresserra-Rimbau, Anna Castañer, Olga Pintó Sala, Xavier Vázquez Ruiz, Zenaida Sorlí, José V. Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Alonso Gómez, Ángel M. Fiol, Miquel Serra Majem, Lluís Sacanella Meseguer, Emilio Razquin, Cristina Corella Piquer, Dolores Guasch-Ferré, Marta Cofán Pujol, Montserrat Estruch Riba, Ramon Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció 613 616.1 There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk. MDPI http://hdl.handle.net/20.500.14342/761 https://doi.org/10.3390/nu13020559 |
| spellingShingle | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial Hernáez, Álvaro Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció 613 616.1 |
| status_str | publishedVersion |
| title | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| title_full | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| title_fullStr | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| title_full_unstemmed | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| title_short | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| title_sort | Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: a randomized controlled trial |
| topic | Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció 613 616.1 |
| topic_facet | Dieta mediterrània Plaquetes sanguínies --Trastorns Trombocitopènia -- Prevenció 613 616.1 |
| url | http://hdl.handle.net/20.500.14342/761 https://doi.org/10.3390/nu13020559 |