Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder
Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients un...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/173784 |
| Online Access: | https://hdl.handle.net/2445/173784 |
| Access Level: | Open access |
| Keyword: | Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages |
| _version_ | 1878732674334457857 |
|---|---|
| author | Hernández Rubio, Anna |
| author2 | Sanvisens, Arantza Bolao, Ferran Pérez Mañá, Clara García Marchena, Nuria Fernández Prendes, Carla Muñoz, Alvaro Muga, Roberto |
| author2_role | author author author author author author author |
| author_browse | Bolao, Ferran Fernández Prendes, Carla García Marchena, Nuria Hernández Rubio, Anna Muga, Roberto Muñoz, Alvaro Pérez Mañá, Clara Sanvisens, Arantza |
| author_facet | Hernández Rubio, Anna Sanvisens, Arantza Bolao, Ferran Pérez Mañá, Clara García Marchena, Nuria Fernández Prendes, Carla Muñoz, Alvaro Muga, Roberto |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4792f4e9bfa50b67966c2ff0f607d9c8 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/173784 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder Hernández Rubio, Anna Sanvisens, Arantza Bolao, Ferran Pérez Mañá, Clara García Marchena, Nuria Fernández Prendes, Carla Muñoz, Alvaro Muga, Roberto Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population. Nature Research https://hdl.handle.net/2445/173784 |
| spellingShingle | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder Hernández Rubio, Anna Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages |
| status_str | publishedVersion |
| title | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| title_full | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| title_fullStr | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| title_full_unstemmed | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| title_short | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| title_sort | Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder |
| topic | Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages |
| topic_facet | Hiperuricèmia Consum d'alcohol Hyperuricemia Drinking of alcoholic beverages |
| url | https://hdl.handle.net/2445/173784 |