Allostatic-interoceptive anticipation of social rejection
Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we a...
| Authors: | ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | Argentina |
| Institution: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repository: | CONICET Digital (CONICET) |
| Language: | English |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/220505 |
| Online Access: | http://hdl.handle.net/11336/220505 |
| Access Level: | Embargoed access |
| Keyword: | ALLOSTATIC INTEROCEPTION SOCIAL REJECTION https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
| _version_ | 1878403801387368448 |
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| author | Migeot, Joaquín |
| author2 | Hesse Rizzi, Eugenia Fátima Fittipaldi, Sol Mejía, Jhonny Fraile, Matías García, Adolfo Martín García, María del Carmen Ortega, Rodrigo Lawlor, Brian Lopez, Vladimir Ibañez, Agustin Mariano |
| author2_role | author author author author author author author author author author |
| author_browse | Fittipaldi, Sol Fraile, Matías García, Adolfo Martín García, María del Carmen Hesse Rizzi, Eugenia Fátima Ibañez, Agustin Mariano Lawlor, Brian Lopez, Vladimir Mejía, Jhonny Migeot, Joaquín Ortega, Rodrigo |
| author_facet | Migeot, Joaquín Hesse Rizzi, Eugenia Fátima Fittipaldi, Sol Mejía, Jhonny Fraile, Matías García, Adolfo Martín García, María del Carmen Ortega, Rodrigo Lawlor, Brian Lopez, Vladimir Ibañez, Agustin Mariano |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress. |
| eu_rights_str_mv | embargoedAccess |
| format | article |
| id | AR_c2ca8a0194e70eacf52fdd0bbc72db21 |
| identifier_str_mv | Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; et al.; Allostatic-interoceptive anticipation of social rejection; Academic Press Inc Elsevier Science; Neuroimage; 276; 8-2023; 1-31 1053-8119 CONICET Digital CONICET |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/220505 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Academic Press Inc Elsevier Science |
| publisherStr | Academic Press Inc Elsevier Science |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Allostatic-interoceptive anticipation of social rejection Migeot, Joaquín Hesse Rizzi, Eugenia Fátima Fittipaldi, Sol Mejía, Jhonny Fraile, Matías García, Adolfo Martín García, María del Carmen Ortega, Rodrigo Lawlor, Brian Lopez, Vladimir Ibañez, Agustin Mariano ALLOSTATIC INTEROCEPTION SOCIAL REJECTION https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 Anticipating social stress evokes strong reactions in the organism, including interoceptive modulations. However, evidence for this claim comes from behavioral studies, often with inconsistent results, and relates almost solely to the reactive and recovery phase of social stress exposure. Here, we adopted an allostatic-interoceptive predictive coding framework to study interoceptive and exteroceptive anticipatory brain responses using a social rejection task. We analyzed the heart-evoked potential (HEP) and task-related oscillatory activity of 58 adolescents via scalp EEG, and 385 human intracranial recordings of three patients with intractable epilepsy. We found that anticipatory interoceptive signals increased in the face of unexpected social outcomes, reflected in larger negative HEP modulations. Such signals emerged from key brain allostatic-interoceptive network hubs, as shown by intracranial recordings. Exteroceptive signals were characterized by early activity between 1-15 Hz across conditions, and modulated by the probabilistic anticipation of reward-related outcomes, observed over distributed brain regions. Our findings suggest that the anticipation of a social outcome is characterized by allostatic-interoceptive modulations that prepare the organism for possible rejection. These results inform our understanding of interoceptive processing and constrain neurobiological models of social stress. Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile Fil: Hesse Rizzi, Eugenia Fátima. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fittipaldi, Sol. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile Fil: Mejía, Jhonny. Universidad Adolfo Ibáñez; Chile Fil: Fraile, Matías. Universidad de San Andrés; Argentina Fil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: García, María del Carmen. Hospital Italiano; Argentina Fil: Ortega, Rodrigo. Universidad Adolfo Ibañez; Chile Fil: Lawlor, Brian. University of California; Estados Unidos Fil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile Academic Press Inc Elsevier Science http://hdl.handle.net/11336/220505 Migeot, Joaquín; Hesse Rizzi, Eugenia Fátima; Fittipaldi, Sol; Mejía, Jhonny; Fraile, Matías; et al.; Allostatic-interoceptive anticipation of social rejection; Academic Press Inc Elsevier Science; Neuroimage; 276; 8-2023; 1-31 1053-8119 CONICET Digital CONICET |
| spellingShingle | Allostatic-interoceptive anticipation of social rejection Migeot, Joaquín ALLOSTATIC INTEROCEPTION SOCIAL REJECTION https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
| status_str | publishedVersion |
| title | Allostatic-interoceptive anticipation of social rejection |
| title_full | Allostatic-interoceptive anticipation of social rejection |
| title_fullStr | Allostatic-interoceptive anticipation of social rejection |
| title_full_unstemmed | Allostatic-interoceptive anticipation of social rejection |
| title_short | Allostatic-interoceptive anticipation of social rejection |
| title_sort | Allostatic-interoceptive anticipation of social rejection |
| topic | ALLOSTATIC INTEROCEPTION SOCIAL REJECTION https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
| topic_facet | ALLOSTATIC INTEROCEPTION SOCIAL REJECTION https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
| url | http://hdl.handle.net/11336/220505 |