Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats
The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fa...
| Autores: | ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2014 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/30363 |
| Acceso en línea: | http://hdl.handle.net/11336/30363 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Cytokines Dyslipidemia Glucose Tolerance High-Fat Diet Hypertension Inflammation Uric Acid https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| _version_ | 1878402830353563648 |
|---|---|
| author | Cano Barquilla, Pilar |
| author2 | Pagano, Eleonora Samanta Jiménez Ortega, Vanesa Fernández Mateos, Pilar Esquifino, Ana I. Cardinali, Daniel Pedro |
| author2_role | author author author author author |
| author_browse | Cano Barquilla, Pilar Cardinali, Daniel Pedro Esquifino, Ana I. Fernández Mateos, Pilar Jiménez Ortega, Vanesa Pagano, Eleonora Samanta |
| author_facet | Cano Barquilla, Pilar Pagano, Eleonora Samanta Jiménez Ortega, Vanesa Fernández Mateos, Pilar Esquifino, Ana I. Cardinali, Daniel Pedro |
| author_role | author |
| collection | CONICET Digital (CONICET) |
| description | The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | AR_0ac1e01fffffaec2fbeedd12cdf1e310 |
| identifier_str_mv | Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-290 0742-3098 1600-079X CONICET Digital CONICET |
| institution | Consejo Nacional de Investigaciones Científicas y Técnicas |
| instname_str | Consejo Nacional de Investigaciones Científicas y Técnicas |
| language | eng |
| network_acronym_str | AR |
| network_name_str | Argentina |
| oai_identifier_str | oai:ri.conicet.gov.ar:11336/30363 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | CONICET Digital (CONICET) |
| spelling | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats Cano Barquilla, Pilar Pagano, Eleonora Samanta Jiménez Ortega, Vanesa Fernández Mateos, Pilar Esquifino, Ana I. Cardinali, Daniel Pedro Cytokines Dyslipidemia Glucose Tolerance High-Fat Diet Hypertension Inflammation Uric Acid https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet. Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid; España Fil: Pagano, Eleonora Samanta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid; España Fil: Fernández Mateos, Pilar. Universidad Complutense de Madrid; España Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Wiley http://hdl.handle.net/11336/30363 Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-290 0742-3098 1600-079X CONICET Digital CONICET |
| spellingShingle | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats Cano Barquilla, Pilar Cytokines Dyslipidemia Glucose Tolerance High-Fat Diet Hypertension Inflammation Uric Acid https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| status_str | publishedVersion |
| title | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| title_full | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| title_fullStr | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| title_full_unstemmed | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| title_short | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| title_sort | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats |
| topic | Cytokines Dyslipidemia Glucose Tolerance High-Fat Diet Hypertension Inflammation Uric Acid https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| topic_facet | Cytokines Dyslipidemia Glucose Tolerance High-Fat Diet Hypertension Inflammation Uric Acid https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| url | http://hdl.handle.net/11336/30363 |